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Peptide record

TPDB10891

Antibacterial Antifungal Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10891
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFLGPLLKLGLKGVAKVIPHLIPSRQQ
Physicochemical Analysis
C136H231N37O31
NDCEMTWY
L
2880.56
11.73
5
0
12
+4
2.28
0.415
140.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
2
Q
4
G
1
H
2
I
6
L
3
K
0
M
1
F
3
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 4 H: 1 I: 2 L: 6 K: 3 M: 0 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
27
C136H231N37O31
2880.56
11.73
+4
2.28
0.415
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
40 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Moderately active against E. coli (MIC 40 uM) and highly active against S. aureus MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemoly
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP

Other

Moderately active against E. coli (MIC 40 uM) and highly active against S. aureus MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemolytic HC50=50 uM. Updated 7/2021
Evidence 3 Activity

Activity

MIC
Antifungal
40 µM

Target

Escherichia coli

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Moderately active against E. coli (MIC 40 uM) and highly active against S. aureus MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemoly
Evidence 4 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Staphylococcus aureus MRSA

Source & Reference

dbAMP Antifungipept

Other

Moderately active against E. coli (MIC 40 uM) and highly active against S. aureus MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemolytic HC50=50 uM. Updated 7/2021
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). | Peptides | 2012
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.