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Peptide record

TPDB10889

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

27 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10889

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 dbACP Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GIGGALLSAGKSALKGLAKGLAEHFAN

FASTA

>TPDB10889|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=27
GIGGALLSAGKSALKGLAKGLAEHFAN

Formula C114H191N33O33

Absent Amino Acids RDCQMPTWYV

Common Amino Acids AG

Mass 2551.97

PI 10.32

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 13

Net Charge +2

Boman Index 1.43

Hydrophobicity 0.415

Aliphatic Index 108.89

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

Amino Acid Distribution

A: 6 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 6 H: 1 I: 1 L: 5 K: 3 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C114H191N33O33

Mass

2551.97

10.32

Net Charge

Boman Index

1.43

Hydrophobicity

0.415

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.3 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M. luteus, and S. cerevisae Ke

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 0.99 µM

Target

Target Organism human hepatic adenocarcinoma SK-HEP-1 cells

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

ve against M. luteus, and S. cerevisae Ke T et al., 2012 . ALso has anticancer effects on human hepatic adenocarcinoma SK-HEP-1 cells (IC50 0.99 uM), Hep G2 cells (IC50 2.8 uM) and Huh7 cells (IC50 3.8 uM) after 48 h treatment, also human

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.3 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M. luteus, and S. cerevisae Ke

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 0.99 µM

Target

Target Organism human hepatic adenocarcinoma SK-HEP-1 cells

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 6.3 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 12.5 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli (MIC6.3 uM), S. aureus (MIC6.3 uM) and C. albicans (MIC12.5uM) (MIC data provided by Chunfeng Wang). Also active against M. luteus, and S. cerevisae Ke

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 0.99 µM

Target

Target Organism human hepatic adenocarcinoma SK-HEP-1 cells

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint 2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire-bellied toad, Bombina orientalis | Chem Biol Drug Des | 2017

Evidence 14 Activity

Activity

Activity Endpoint 83% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

83% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire-bellied toad, Bombina orientalis | Chem Biol Drug Des | 2017

Evidence 15 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur J Immunol. 2005 Apr 35(4):1220-1229.##Peptides. 2002 Mar 23(3):427-435.