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Peptide record

TPDB10884

Antibacterial Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10884
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
KRFWPLVPVAINTVAAGINLYKAIRRK
Physicochemical Analysis
C146H240N42O32
DCEQHMS
A
3095.77
12.15
6
0
15
+6
0.85
0.185
119.26
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
6990
225.79
4
Residue Composition
number
4
A
3
R
2
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
3
K
0
M
1
F
2
P
0
S
1
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 4 R: 3 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 2 S: 0 T: 1 W: 1 Y: 1 V: 3
Chemical Descriptors
27
C146H240N42O32
3095.77
12.15
+6
0.85
0.185
Evidence Records 5 records
Evidence 1 Activity

Activity

88.1% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
88.1% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The Central Hinge Link Truncation of the Antimicrobial Peptide Fowlicidin-3 Enhances Its Cell Selectivity without Antibacterial Activity Loss. | Antimicrob Agents Chemother | 2016
Evidence 2 Activity

Activity

>70% Killing
Toxicity
256 µM
Cytotoxic
>70% Killing | 256 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
The Central Hinge Link Truncation of the Antimicrobial Peptide Fowlicidin-3 Enhances Its Cell Selectivity without Antibacterial Activity Loss. | Antimicrob Agents Chemother | 2016
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
9 µM
Hemolytic Cytotoxic
50% Hemolysis | 9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. | FEBS J | 2007
Evidence 4 Activity

Activity

50% Cell death
Toxicity
12 µM
Cytotoxic
50% Cell death | 12 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Fowlicidin-3 is an alpha-helical cationic host defense peptide with potent antibacterial and lipopolysaccharide-neutralizing activities. | FEBS J | 2007
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis