Back to search

Peptide record

TPDB10882

Antibacterial Antifungal Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10882
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFVLKFLLKWAGKVGLEHLACKFKNWC
Physicochemical Analysis
C159H237N37O31S2
RDQIMPSTY
LK
3226.98
10.06
6
1
15
+4
-3.33
0.552
101.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11125
344.75
3
Residue Composition
number
2
A
0
R
1
N
0
D
2
C
1
E
0
Q
2
G
1
H
0
I
5
L
5
K
0
M
4
F
0
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 5 K: 5 M: 0 F: 4 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
27
C159H237N37O31S2
3226.98
10.06
+4
-3.33
0.552
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 66
Evidence 2 Activity

Activity

MIC
Antibacterial
1.5 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albic
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.5 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

22 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 66
Evidence 7 Activity

Activity

MIC
Antifungal
1.5 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albic
Evidence 8 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
1.5 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

22 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 11 Activity

Activity

% Hemolysis
Hemolysis
3.9 13.7 27.7 45.3 5.6 15.2 36.2 50.3 %
[Ref.27114317] Human red blood cells: 3.9% hemolysis at 25µg/ml 13.7% hemolysis at 50µg/ml 27.7% hemolysis at 100µg/ml 45.3% hemolysis at 200µg/ml Rabbit red blood cells: 5.6% hemolysis at 25µg/ml 15.2% hemolysis at 50µg/ml 36.2% hemolysis at 100µg/ml 50.3% hemolysis at 200 µg/ml

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Chin J Nat Med. 2016 Apr 14(4):294-298.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 12 Activity

Activity

4% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 13 Activity

Activity

14% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
14% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 14 Activity

Activity

28% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
28% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 15 Activity

Activity

45% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 16 Activity

Activity

6% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 25 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 17 Activity

Activity

15% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 18 Activity

Activity

36% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
36% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 20 Activity

Activity

% Hemolysis
Toxicity
3.9 %
Hemolytic
Hemolytic_activity: [Ref.27114317] Human red blood cells: 3.9% hemolysis at 25µg/ml 13.7% hemolysis at 50µg/ml 27.7% hemolysis at 100µg/ml 45.3% hemolysis at 200µg/ml Rabbit red blood cells: 5.6% hemolysis at 25µg/ml 15.2% hemolysis at 50µg/ml 36.2% hemolysis at 100µg/ml 50.3% hemolysis at 200 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Chin J Nat Med. 2016 Apr 14(4):294-298.
Evidence 21 Hemolysis

Activity

3.9 13.7 27.7 45.3 5.6 15.2 36.2 50.3 %
% Hemolysis
[Ref.27114317] Human red blood cells: 3.9% hemolysis at 25µg/ml 13.7% hemolysis at 50µg/ml 27.7% hemolysis at 100µg/ml 45.3% hemolysis at 200µg/ml Rabbit red blood cells: 5.6% hemolysis at 25µg/ml 15.2% hemolysis at 50µg/ml 36.2% hemolysis at 100µg/ml 50.3% hemolysis at 200 µg/ml
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Chin J Nat Med. 2016 Apr 14(4):294-298.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.