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Peptide record

TPDB10882

Antibacterial Antifungal Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10882
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFVLKFLLKWAGKVGLEHLACKFKNWC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C159H237N37O31S2
RDQIMPSTY
LK
3226.98
10.06
6
1
15
+4
-0.42
0.552
101.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11125
3.45
3
Residue Composition
number
2
A
0
R
1
N
0
D
2
C
1
E
0
Q
2
G
1
H
0
I
5
L
5
K
0
M
4
F
0
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 1 I: 0 L: 5 K: 5 M: 0 F: 4 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
27 reviewed residue count
C159H237N37O31S2 sequence-only estimate (linear, free termini)
3226.98 sequence-only estimate (linear, free termini)
10.06 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.42 sequence-only estimate (linear, free termini)
0.552 sequence-only estimate (linear, free termini)
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 66
Evidence 2 Activity

Activity

MIC
Antibacterial
1.5 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albic
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.5 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

22 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 66
Evidence 7 Activity

Activity

MIC
Antifungal
1.5 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albic
Evidence 8 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Staphylococcus aureus ATCC2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25922 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
1.5 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

22 (MIC 6.25 ug/ml), B. dysenteriae (MIC 1.5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 ug/ml), S. aureus ATCC2592 (MIC 12.5 ug/ml), B. subtilis ATCC 6633 (MIC 1.5 ug/ml), and C. albicans ATCC2002 (MIC 12.5 ug/ml).
Evidence 11 Activity

Activity

% Hemolysis
Hemolysis
3.9 13.7 27.7 45.3 5.6 15.2 36.2 50.3 %
[Ref.27114317] Human red blood cells: 3.9% hemolysis at 25µg/ml 13.7% hemolysis at 50µg/ml 27.7% hemolysis at 100µg/ml 45.3% hemolysis at 200µg/ml Rabbit red blood cells: 5.6% hemolysis at 25µg/ml 15.2% hemolysis at 50µg/ml 36.2% hemolysis at 100µg/ml 50.3% hemolysis at 200 µg/ml

Target

Human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Chin J Nat Med. 2016 Apr 14(4):294-298.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 12 Activity

Activity

4% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 13 Activity

Activity

14% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
14% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 14 Activity

Activity

28% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
28% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 15 Activity

Activity

45% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 16 Activity

Activity

6% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 25 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 17 Activity

Activity

15% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 18 Activity

Activity

36% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
36% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from skin venoms of spadefoot toad Megophrys minor. | Chin J Nat Med | 2016
Evidence 20 Activity

Activity

% Hemolysis
Toxicity
3.9 %
Hemolytic
Hemolytic_activity: [Ref.27114317] Human red blood cells: 3.9% hemolysis at 25µg/ml 13.7% hemolysis at 50µg/ml 27.7% hemolysis at 100µg/ml 45.3% hemolysis at 200µg/ml Rabbit red blood cells: 5.6% hemolysis at 25µg/ml 15.2% hemolysis at 50µg/ml 36.2% hemolysis at 100µg/ml 50.3% hemolysis at 200 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Chin J Nat Med. 2016 Apr 14(4):294-298.
Evidence 21 Hemolysis

Activity

3.9 13.7 27.7 45.3 5.6 15.2 36.2 50.3 %
% Hemolysis
[Ref.27114317] Human red blood cells: 3.9% hemolysis at 25µg/ml 13.7% hemolysis at 50µg/ml 27.7% hemolysis at 100µg/ml 45.3% hemolysis at 200µg/ml Rabbit red blood cells: 5.6% hemolysis at 25µg/ml 15.2% hemolysis at 50µg/ml 36.2% hemolysis at 100µg/ml 50.3% hemolysis at 200 µg/ml
Hemolysis

Target

Human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Chin J Nat Med. 2016 Apr 14(4):294-298.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.