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Peptide record

TPDB10881

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB10881
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLGPLLKLGLKGAAKLLPQLLPSRQQ
Physicochemical Analysis
C134H230N36O32
NDCEHIMTWYV
L
2857.52
11.73
4
0
12
+4
0.53
0.248
137.41
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
3
Q
4
G
0
H
0
I
9
L
3
K
0
M
1
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 4 H: 0 I: 0 L: 9 K: 3 M: 0 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27
C134H230N36O32
2857.52
11.73
+4
0.53
0.248
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
40 µM

Target

Escherichia coli ATCC 25726

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Moderately active against E. coli ATCC 25726 (MIC 40 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5 uM). In vitro Toxicity:
Evidence 2 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

Staphylococcus aureus ATCC 25923 and MRSA

Source & Reference

dbAMP DRAMP

Other

Moderately active against E. coli ATCC 25726 (MIC 40 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemolytic HC50 50 uM (?).
Evidence 3 Activity

Activity

MIC
Antifungal
40 µM

Target

Escherichia coli ATCC 25726

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Moderately active against E. coli ATCC 25726 (MIC 40 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5 uM). In vitro Toxicity:
Evidence 4 Activity

Activity

MIC
Antifungal
2.5 µM

Target

Staphylococcus aureus ATCC 25923 and MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Moderately active against E. coli ATCC 25726 (MIC 40 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemolytic HC50 50 uM (?).
Evidence 5 Activity

Activity

MIC
Antiparasitic
40 µM

Target

Escherichia coli ATCC 25726

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Moderately active against E. coli ATCC 25726 (MIC 40 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5 uM). In vitro Toxicity:
Evidence 6 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

Staphylococcus aureus ATCC 25923 and MRSA

Source & Reference

DRAMP

Other

Moderately active against E. coli ATCC 25726 (MIC 40 uM) and highly active against S. aureus ATCC 25923 and MRSA (MIC 2.5 uM). In vitro Toxicity: moderate hemolytic HC50 50 uM (?).
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
50% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). | Peptides | 2012
Evidence 8 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.