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Peptide record

TPDB10860

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10860
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb i2APP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFIKKLTSAAKKVVTTAKPLISS
Physicochemical Analysis
C134H230N34O34
RNDCEQGHMY
K
2861.51
11.29
7
0
11
+7
3.23
-0.073
93.85
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
192.21
7
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
7
K
0
M
1
F
1
P
4
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 7 M: 0 F: 1 P: 1 S: 4 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C134H230N34O34
2861.51
11.29
+7
3.23
-0.073
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active aga
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

Escherichia coli UB1005

Source & Reference

dbAMP DRAMP

Other

active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium 14028s

Source & Reference

dbAMP DRAMP

Other

ainst P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemol
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Staphylococcus aureus ATCC 25923 or SAP0017 MRSA

Source & Reference

dbAMP DRAMP

Other

B1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 2
Evidence 5 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus haemolyticus

Source & Reference

dbAMP DRAMP

Other

2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monoc
Evidence 6 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyog
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

L. monocytogenes NCTC 7973

Source & Reference

dbAMP DRAMP

Other

C 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedri
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP DRAMP

Other

ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedrich et al., 2000 ).
Evidence 9 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

C. xerosis lab strain

Source & Reference

dbAMP DRAMP

Other

l), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedrich et al., 2000 ).
Evidence 10 Activity

Activity

MIC
Antifungal
2-4 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active aga
Evidence 11 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

Escherichia coli UB1005

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923
Evidence 12 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. typhimurium 14028s

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemol
Evidence 13 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Staphylococcus aureus ATCC 25923 or SAP0017 MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 2
Evidence 14 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus haemolyticus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monoc
Evidence 15 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyog
Evidence 16 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

L. monocytogenes NCTC 7973

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedri
Evidence 17 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedrich et al., 2000 ).
Evidence 18 Activity

Activity

MIC
Antifungal
1 µg/mL

Target

C. xerosis lab strain

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedrich et al., 2000 ).
Evidence 19 Activity

Activity

MIC
Antiparasitic
2-4 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active aga
Evidence 20 Activity

Activity

MIC
Antiparasitic
0.5 µg/mL

Target

Escherichia coli UB1005

Source & Reference

DRAMP

Other

active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923
Evidence 21 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

S. typhimurium 14028s

Source & Reference

DRAMP

Other

ainst P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemol
Evidence 22 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

Staphylococcus aureus ATCC 25923 or SAP0017 MRSA

Source & Reference

DRAMP

Other

B1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 2
Evidence 23 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Staphylococcus haemolyticus

Source & Reference

DRAMP

Other

2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monoc
Evidence 24 Activity

Activity

MIC
Antiparasitic
32 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

aureus ATCC 25923 or SAP0017 MRSA (MIC 64 ug/ml), S. haemolyticus (MIC 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyog
Evidence 25 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

L. monocytogenes NCTC 7973

Source & Reference

DRAMP

Other

C 64 uM) or greater, S. epidermidis (MIC 32 ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedri
Evidence 26 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

DRAMP

Other

ug/ml), E-faecalis ATCC 29212 (MIC>64 ug/ml), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedrich et al., 2000 ).
Evidence 27 Activity

Activity

MIC
Antiparasitic
1 µg/mL

Target

C. xerosis lab strain

Source & Reference

DRAMP

Other

l), L. monocytogenes NCTC 7973 (MIC 16 ug/ml), S. pyogenes ATCC 19615 (MIC 16 ug/ml), and C. xerosis lab strain (MIC 1 ug/ml) ( Friedrich et al., 2000 ).
Evidence 28 Activity

Activity

<10% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | >128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of proline residues on the antibacterial and synergistic activities of alpha-helical peptides. | Biochemistry | 1999
Evidence 29 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis