Back to search

Peptide record

TPDB10856

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10856
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 i2APP ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
HRHQGPIFDTRPSPFNPNQPRPGPIY
Physicochemical Analysis
C137H201N43O36
ACELKMWV
P
3026.37
11.06
5
1
5
+2
7.20
-1.446
30.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
49.23
7
Residue Composition
number
0
A
3
R
2
N
1
D
0
C
0
E
2
Q
2
G
2
H
2
I
0
L
0
K
0
M
2
F
7
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 1 C: 0 E: 0 Q: 2 G: 2 H: 2 I: 2 L: 0 K: 0 M: 0 F: 2 P: 7 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
26
C137H201N43O36
3026.37
11.06
+2
7.20
-1.446
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P Tonk et al. 2019 ).
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-1.0 µM

Target

N. crassa

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P Tonk et al. 2019 ).
Evidence 3 Activity

Activity

MIC
Antifungal
0.5-1 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P Tonk et al. 2019 ).
Evidence 4 Activity

Activity

MIC
Antifungal
0.5-1.0 µM

Target

N. crassa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P Tonk et al. 2019 ).
Evidence 5 Activity

Activity

MIC
Antiparasitic
0.5-1 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P Tonk et al. 2019 ).
Evidence 6 Activity

Activity

MIC
Antiparasitic
0.5-1.0 µM

Target

N. crassa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against M. luteus (MIC 0.5-1 uM), and N. crassa (MIC 0.5-1.0 uM). It showed significant (P Tonk et al. 2019 ).
Evidence 7 Activity

Activity

1% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
1% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. | Int J Antimicrob Agents | 2010
Evidence 8 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Evidence 9 Activity

Activity

12% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
12% Hemolysis | 100 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019