TPDB

3D PDB MODEL

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TPDB ID TPDB10853

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FWGHIWNAVKRVGANALHGAVTGALS

FASTA

>TPDB10853|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=26
FWGHIWNAVKRVGANALHGAVTGALS

Formula C126H190N38O31

Absent Amino Acids DCEQMPY

Common Amino Acids A

Mass 2733.13

PI 11.49

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 14

Net Charge +2

Boman Index -2.03

Hydrophobicity 0.377

Aliphatic Index 97.69

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 402.47

Polar Residues 4

number

5

A

1

R

2

N

0

D

0

C

0

E

0

Q

4

G

2

H

1

I

2

L

1

K

0

M

1

F

0

P

1

S

1

T

2

W

0

Y

3

V

Amino Acid Distribution

A: 5 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 2 I: 1 L: 2 K: 1 M: 0 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 0 V: 3

Length

26

Formula

C126H190N38O31

Mass

2733.13

PI

11.49

Net Charge

+2

Boman Index

-2.03

Hydrophobicity

0.377

Evidence 1 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 8 13 14 22 %

Hemolysis Raw

[Ref.19085906]8% hemolytic activity at 6.25 µM, 13% hemolytic activity at 12.5 µM, 14% hemolytic activity at 25 µM, 22% hemolytic activity at 50 µM against sheep erythrocytes

Target

RBC Target sheep erythrocytes

Source & Reference

Database Source Hemolytik APD_complete PD_Hemolysis

Source DRAMP4

Reference

J Pept Sci. 2009 Jan 15(1):48-55.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 22% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

22% Hemolysis | 50 | µM | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa. | J Pept Sci | 2009

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.19085906]8% hemolytic activity at 6.25 µM, 13% hemolytic activity at 12.5 µM, 14% hemolytic activity at 25 µM, 22% hemolytic activity at 50 µM against sheep erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Pept Sci. 2009 Jan 15(1):48-55.

Evidence 4 Hemolysis

Activity

Activity Measurement 8 13 14 22 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.19085906]8% hemolytic activity at 6.25 µM, 13% hemolytic activity at 12.5 µM, 14% hemolytic activity at 25 µM, 22% hemolytic activity at 50 µM against sheep erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target sheep erythrocytes

Source & Reference

source APD_complete HemoPI PD_Hemolysis

Reference

J Pept Sci. 2009 Jan 15(1):48-55.

Source DRAMP4

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.