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Peptide record

TPDB10849

Antibacterial Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10849
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 26-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GTFIKQQRKQKQQRHHTSGTRKRMAK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C133H230N52O36S1
NDCELPWYV
QK
3165.68
12.89
11
0
4
+9
4.68
-2.081
18.85
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
9
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
5
Q
2
G
2
H
1
I
0
L
5
K
1
M
1
F
0
P
1
S
3
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 5 G: 2 H: 2 I: 1 L: 0 K: 5 M: 1 F: 1 P: 0 S: 1 T: 3 W: 0 Y: 0 V: 0
Chemical Descriptors
26 reviewed residue count
C133H230N52O36S1 sequence-only estimate (linear, free termini)
3165.68 sequence-only estimate (linear, free termini)
12.89 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
4.68 sequence-only estimate (linear, free termini)
-2.081 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Escherichia coli ATCC 11775

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 11775 (MIC 64 ug/ml). Note that the mature sequence may differ from the synthetic peptide used here.
Evidence 2 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Escherichia coli ATCC 11775

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 11775 (MIC 64 ug/ml). Note that the mature sequence may differ from the synthetic peptide used here.
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
De Novo Transcriptome Analysis and Detection of Antimicrobial Peptides of the American Cockroach Periplaneta americana (Linnaeus). | PLoS One | 2016