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Peptide record

TPDB10843

Antibacterial Anticancer Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10843
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFLKTFKSAAKTVLHTALKAISS
Physicochemical Analysis
C136H223N35O34
RNDCEQGMPY
K
2892.48
11.21
7
0
12
+6
1.13
0.004
86.54
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
190.15
7
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
3
L
6
K
0
M
2
F
0
P
4
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 6 M: 0 F: 2 P: 0 S: 4 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C136H223N35O34
2892.48
11.21
+6
1.13
0.004
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli ATCC 25922 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aure
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli ATCC 25922 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 4 uM), S. epidermi
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli ATCC 25922 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoni
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

C 2 uM), P. aeruginosa ATCC 27853 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

(MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. pneumoniae ATCC 49619

Source & Reference

dbAMP DRAMP

Other

(MIC 4 uM), Gram+ S. aureus ATCC 25923 (MIC 4 uM), S. epidermidis ATCC 12228 (MIC 4 uM), S. pneumoniae ATCC 49619 (MIC 2 uM).
Evidence 7 Activity

Activity

MHC
Hemolysis
31.2 µg/mL
[Ref.15677462]MHC=31.2 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Biol Chem. 2005 Apr 1 280(13):12316-29.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

MHC
Hemolysis
250.0 µg/mL
[Ref.15677462]MHC=250.0 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
J Biol Chem. 2005 Apr 1 280(13):12316-29.
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
<5% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 10 Activity

Activity

50% Cell death
Toxicity
6.79 µM
Cytotoxic
50% Cell death | 6.79 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 11 Activity

Activity

MHC
Toxicity
31.2 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC=31.2 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.
Evidence 12 Activity

Activity

MHC
Toxicity
250.0 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC=250.0 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.
Evidence 13 Hemolysis

Activity

31.2 µg/mL
MHC
[Ref.15677462]MHC=31.2 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
J Biol Chem. 2005 Apr 1 280(13):12316-29.
DRAMP4
PD_Hemolysis
Evidence 14 Hemolysis

Activity

250.0 µg/mL
MHC
[Ref.15677462]MHC=250.0 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

HemoPI PD_Hemolysis
J Biol Chem. 2005 Apr 1 280(13):12316-29.
DRAMP4
PD_Hemolysis