Back to search

Peptide record

TPDB10842

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10842
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIEKVGQGIGAVLKVLTTGL
Physicochemical Analysis
C136H232N34O32
RNDCHMPSY
K
2855.55
10.82
6
1
12
+5
3.06
0.273
127.31
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
192.61
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
1
Q
4
G
0
H
2
I
4
L
6
K
0
M
1
F
0
P
0
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 4 H: 0 I: 2 L: 4 K: 6 M: 0 F: 1 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
26
C136H232N34O32
2855.55
10.82
+5
3.06
0.273
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
Antibacterial
17 µM

Target

P. falciparum

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ureus Cowan 1 (LC 2 uM), and S. pyogenes (LC 1 uM). ActivityG: D=L. Antimalarial activity:P. falciparum (IC50 17 uM). ActivityP:L>D.
Evidence 2 Activity

Activity

IC50
Antifungal
17 µM

Target

P. falciparum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ureus Cowan 1 (LC 2 uM), and S. pyogenes (LC 1 uM). ActivityG: D=L. Antimalarial activity:P. falciparum (IC50 17 uM). ActivityP:L>D.
Evidence 3 Activity

Activity

IC50
Antiparasitic
17 µM

Target

P. falciparum

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
ureus Cowan 1 (LC 2 uM), and S. pyogenes (LC 1 uM). ActivityG: D=L. Antimalarial activity:P. falciparum (IC50 17 uM). ActivityP:L>D.
Evidence 4 Activity

Activity

12% Hemolysis
Toxicity
10 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cecropin A-melittin mutant with improved proteolytic stability and enhanced antimicrobial activity against bacteria and fungi associated with gastroenteritis in vitro. | Biochem Biophys Res Commun | 2014
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>300 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cecropin A-melittin mutant with improved proteolytic stability and enhanced antimicrobial activity against bacteria and fungi associated with gastroenteritis in vitro. | Biochem Biophys Res Commun | 2014
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis