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Peptide record

TPDB10840

Antibacterial Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10840
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
VAPIAKYLATALAKWALKQGFAKLKS
Physicochemical Analysis
C134H219N33O31
RNDCEHM
A
2788.42
10.77
5
0
16
+5
-1.33
0.408
113.08
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
250.68
4
Residue Composition
number
7
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
4
L
5
K
0
M
1
F
1
P
1
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 4 K: 5 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
26
C134H219N33O31
2788.42
10.77
+5
-1.33
0.408
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

At 7.1 uM, this synthetic peptide inhibited the growth of E. coli ATCC 25922, S. aureus ATCC 25923, S. pneumoniae ATCC 49619, H. influenzae ATCC 49247, E. faecalis ATCC 29212, P. aeruginosa ATCC27603, P. aeruginosa (Multi-Resistant), and K. pneumoniae ATCC70603 ( Segura C et al., 2007 ). In addition, the protease-resistant BTM-P1d (i.e., synthesized using D-amino acids), not the BTM-P1 synthesized in L-amino acids, displayed A. aegypti larval toxicity ( Lemeshko VV, Orduz S., 2013 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

At 7.1 uM, this synthetic peptide inhibited the growth of E. coli ATCC 25922, S. aureus ATCC 25923, S. pneumoniae ATCC 49619, H. influenzae ATCC 49247, E. faecalis ATCC 29212, P. aeruginosa ATCC27603, P. aeruginosa (Multi-Resistant), and K. pneumoniae ATCC70603 ( Segura C et al., 2007 ). In addition, the protease-resistant BTM-P1d (i.e., synthesized using D-amino acids), not the BTM-P1 synthesized in L-amino acids, displayed A. aegypti larval toxicity ( Lemeshko VV, Orduz S., 2013 ).