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Peptide record

TPDB10840

Antibacterial Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10840
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 26-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
VAPIAKYLATALAKWALKQGFAKLKS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C134H219N33O31
RNDCEHM
A
2788.42
10.77
5
0
16
+5
-0.31
0.408
113.08
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6990
2.51
4
Residue Composition
number
7
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
4
L
5
K
0
M
1
F
1
P
1
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 4 K: 5 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
26 reviewed residue count
C134H219N33O31 sequence-only estimate (linear, free termini)
2788.42 sequence-only estimate (linear, free termini)
10.77 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
-0.31 sequence-only estimate (linear, free termini)
0.408 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

At 7.1 uM, this synthetic peptide inhibited the growth of E. coli ATCC 25922, S. aureus ATCC 25923, S. pneumoniae ATCC 49619, H. influenzae ATCC 49247, E. faecalis ATCC 29212, P. aeruginosa ATCC27603, P. aeruginosa (Multi-Resistant), and K. pneumoniae ATCC70603 ( Segura C et al., 2007 ). In addition, the protease-resistant BTM-P1d (i.e., synthesized using D-amino acids), not the BTM-P1 synthesized in L-amino acids, displayed A. aegypti larval toxicity ( Lemeshko VV, Orduz S., 2013 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

At 7.1 uM, this synthetic peptide inhibited the growth of E. coli ATCC 25922, S. aureus ATCC 25923, S. pneumoniae ATCC 49619, H. influenzae ATCC 49247, E. faecalis ATCC 29212, P. aeruginosa ATCC27603, P. aeruginosa (Multi-Resistant), and K. pneumoniae ATCC70603 ( Segura C et al., 2007 ). In addition, the protease-resistant BTM-P1d (i.e., synthesized using D-amino acids), not the BTM-P1 synthesized in L-amino acids, displayed A. aegypti larval toxicity ( Lemeshko VV, Orduz S., 2013 ).