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Peptide record

TPDB10837

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

26 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10837

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia i2APP HemoPI Hemolytic2 PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KWKSFLKTFKSAVKTVLHTALKAISS

FASTA

>TPDB10837|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=26
KWKSFLKTFKSAVKTVLHTALKAISS

Formula C138H227N35O34

Absent Amino Acids RNDCEQGMPY

Common Amino Acids K

Mass 2920.53

PI 11.21

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +6

Boman Index 1.37

Hydrophobicity 0.096

Aliphatic Index 93.85

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 188.32

Polar Residues 7

number

Amino Acid Distribution

A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 6 M: 0 F: 2 P: 0 S: 4 T: 3 W: 1 Y: 0 V: 2

Length

Formula

C138H227N35O34

Mass

2920.53

11.21

Net Charge

Boman Index

1.37

Hydrophobicity

0.096

Evidence 1 Activity

Activity

Activity Endpoint MHC

Detail Source Activity Hemolysis

Activity Measurement 15.6 µg/mL

Hemolysis Raw

[Ref.15677462]MHC=15.6 µg/ml against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

J Biol Chem. 2005 Apr 1 280(13):12316-29.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint MHC

Detail Source Activity Hemolysis

Activity Measurement 62.5 µg/mL

Hemolysis Raw

[Ref.15677462]MHC=62.5 µg/ml against human red blood cells

Target

RBC Target human red blood cells

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

J Biol Chem. 2005 Apr 1 280(13):12316-29.

Evidence 3 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 80 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 80 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. | J Biol Chem | 2008

Evidence 4 Activity

Activity

Activity Endpoint 66% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

66% Hemolysis | 2500 | µg/mL | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides. | J Biol Chem | 2008

Evidence 5 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 15.6 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 15.6 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index | J Biol Chem | 2005

Evidence 6 Activity

Activity

Activity Endpoint <10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 8 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<10% Hemolysis | 8 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Influence of proline residues on the antibacterial and synergistic activities of alpha-helical peptides. | Biochemistry | 1999

Evidence 7 Activity

Activity

Activity Endpoint MHC

Detail Source Activity Toxicity

Activity Measurement 15.6 µg/mL

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15677462]MHC=15.6 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 2005 Apr 1 280(13):12316-29.

Evidence 8 Activity

Activity

Activity Endpoint MHC

Detail Source Activity Toxicity

Activity Measurement 62.5 µg/mL

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.15677462]MHC=62.5 µg/ml against human red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Biol Chem. 2005 Apr 1 280(13):12316-29.

Evidence 9 Hemolysis

Activity

Activity Measurement 15.6 µg/mL

Activity Endpoint MHC

Hemolysis Raw

[Ref.15677462]MHC=15.6 µg/ml against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source HemoPI PD_Hemolysis

Reference

J Biol Chem. 2005 Apr 1 280(13):12316-29.

Source DRAMP4

Database Source PD_Hemolysis

Evidence 10 Hemolysis

Activity

Activity Measurement 62.5 µg/mL

Activity Endpoint MHC

Hemolysis Raw

[Ref.15677462]MHC=62.5 µg/ml against human red blood cells

Detail Source Activity Hemolysis

Target

RBC Target human red blood cells

Source & Reference

source HemoPI PD_Hemolysis

Reference

J Biol Chem. 2005 Apr 1 280(13):12316-29.

Source DRAMP4

Database Source PD_Hemolysis