Peptide record

TPDB10835

Antibacterial Anticancer Antifungal Antiparasitic standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10835
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
KRFGRLAKSFLRMRILLPRRKILLAS
Physicochemical Analysis
C144H255N47O29S1
NDCEQHTWYV
RL
3140.97
13.10
9
0
13
+9
1.74
0.023
127.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
6
L
3
K
1
M
2
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 6 K: 3 M: 1 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C144H255N47O29S1
3140.97
13.10
+9
1.74
0.023
Evidence Records 42 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

Escherichia coli ATCC 25922 or ML 35

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Potently active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K.
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

ently active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP

Other

ria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50
Evidence 4 Activity

Activity

MIC
Antibacterial
3-6 µg/mL

Target

Klebsiella pneumoniae ATCC 13883 or SK1

Source & Reference

dbAMP

Other

ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml),
Evidence 5 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP

Other

. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm
Evidence 6 Activity

Activity

MIC
Antibacterial
6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP

Other

moniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCA
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Streptococcus equinus

Source & Reference

dbAMP

Other

S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fu
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

B. megaterium Bm11

Source & Reference

dbAMP

Other

MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fungi: Active against fungi various C. neof
Evidence 9 Activity

Activity

MIC
Antibacterial
6-12.5 µg/mL

Target

C. neoformans

Source & Reference

dbAMP

Other

ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fungi: Active against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml
Evidence 10 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

R. rubra

Source & Reference

dbAMP

Other

and eCATH-3 in MHB. Fungi: Active against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100
Evidence 11 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

C.albicans

Source & Reference

dbAMP

Other

e against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 u
Evidence 12 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

C.parapsilosis

Source & Reference

dbAMP

Other

neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium
Evidence 13 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

C.tropicalis

Source & Reference

dbAMP

Other

. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium and RPMI ( Skerlavaj B et al.,
Evidence 14 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.etchellsii

Source & Reference

dbAMP

Other

lbicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium and RPMI ( Skerlavaj B et al., 2001 ). It also kills Trypanozoon
Evidence 15 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

Escherichia coli ATCC 25922 or ML 35

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Potently active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K.
Evidence 16 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ently active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml
Evidence 17 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50
Evidence 18 Activity

Activity

MIC
Antifungal
3-6 µg/mL

Target

Klebsiella pneumoniae ATCC 13883 or SK1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml),
Evidence 19 Activity

Activity

MIC
Antifungal
25-50 µg/mL

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm
Evidence 20 Activity

Activity

MIC
Antifungal
6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP CAFPdb Antifungipept

Other

moniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCA
Evidence 21 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Streptococcus equinus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fu
Evidence 22 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

B. megaterium Bm11

Source & Reference

dbAMP CAFPdb Antifungipept

Other

MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fungi: Active against fungi various C. neof
Evidence 23 Activity

Activity

MIC
Antifungal
6-12.5 µg/mL

Target

C. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fungi: Active against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml
Evidence 24 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

R. rubra

Source & Reference

dbAMP CAFPdb Antifungipept

Other

and eCATH-3 in MHB. Fungi: Active against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100
Evidence 25 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

e against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 u
Evidence 26 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

C.parapsilosis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium
Evidence 27 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

C.tropicalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium and RPMI ( Skerlavaj B et al.,
Evidence 28 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.etchellsii

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lbicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium and RPMI ( Skerlavaj B et al., 2001 ). It also kills Trypanozoon
Evidence 29 Activity

Activity

MIC
Antiparasitic
3 µg/mL

Target

Escherichia coli ATCC 25922 or ML 35

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Potently active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K.
Evidence 30 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

ently active against a broad range of bacteria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml
Evidence 31 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

S. marcescens ATCC 8100

Source & Reference

dbAMP 3.0

Other

ria E. coli ATCC 25922 or ML 35 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50
Evidence 32 Activity

Activity

MIC
Antiparasitic
3-6 µg/mL

Target

Klebsiella pneumoniae ATCC 13883 or SK1

Source & Reference

dbAMP 3.0

Other

ml), P. aeruginosa ATCC 27853 (MIC 12.5 ug/ml), S. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml),
Evidence 33 Activity

Activity

MIC
Antiparasitic
25-50 µg/mL

Target

Staphylococcus aureus ATCC 25923 or MRSA

Source & Reference

dbAMP 3.0

Other

. marcescens ATCC 8100 (MIC 12.5 ug/ml), K. pneumoniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm
Evidence 34 Activity

Activity

MIC
Antiparasitic
6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP 3.0

Other

moniae ATCC 13883 or SK1 (MIC 3-6 ug/ml), S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCA
Evidence 35 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

Streptococcus equinus

Source & Reference

dbAMP 3.0

Other

S. aureus ATCC 25923 or MRSA (MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fu
Evidence 36 Activity

Activity

MIC
Antiparasitic
12.5 µg/mL

Target

B. megaterium Bm11

Source & Reference

dbAMP 3.0

Other

MIC 25-50 ug/ml), S. epidermidis ATCC 12228 (MIC 6 ug/ml), S. equinus (MIC 25 ug/ml), and B. megaterium Bm11 (MIC 12.5 ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fungi: Active against fungi various C. neof
Evidence 37 Activity

Activity

MIC
Antiparasitic
6-12.5 µg/mL

Target

C. neoformans

Source & Reference

dbAMP 3.0

Other

ug/ml). More active than eCATH-2 and eCATH-3 in MHB. Fungi: Active against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml
Evidence 38 Activity

Activity

MIC
Antiparasitic
50 µg/mL

Target

R. rubra

Source & Reference

dbAMP 3.0

Other

and eCATH-3 in MHB. Fungi: Active against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100
Evidence 39 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

C.albicans

Source & Reference

dbAMP 3.0

Other

e against fungi various C. neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 u
Evidence 40 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

C.parapsilosis

Source & Reference

dbAMP 3.0

Other

neoformans (MIC 6-12.5 ug/ml), R. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium
Evidence 41 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

C.tropicalis

Source & Reference

dbAMP 3.0

Other

. rubra (MIC 50 ug/ml) but not C.albicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium and RPMI ( Skerlavaj B et al.,
Evidence 42 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

P.etchellsii

Source & Reference

dbAMP 3.0

Other

lbicans (MIC>100 ug/ml),C.parapsilosis (MIC>100 ug/ml), C.tropicalis (MIC>100 ug/ml), and P.etchellsii (MIC>100 ug/ml) in both Sabouraud medium and RPMI ( Skerlavaj B et al., 2001 ). It also kills Trypanozoon