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Peptide record

TPDB10831

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10831
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFIKKLTTAVKKVLTTGLPALIS
Physicochemical Analysis
C137H235N33O33
RNDCEQHMY
K
2872.57
11.21
6
0
12
+6
1.18
0.319
120.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
191.47
6
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
4
L
6
K
0
M
1
F
1
P
2
S
4
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 6 M: 0 F: 1 P: 1 S: 2 T: 4 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C137H235N33O33
2872.57
11.21
+6
1.18
0.319
Evidence Records 31 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active aga
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

Escherichia coli UB1005

Source & Reference

dbAMP DRAMP

Other

active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium 14028s

Source & Reference

dbAMP DRAMP

Other

ainst P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemoly
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Staphylococcus aureus ATCC 25923 or SAP0017 MRSA

Source & Reference

dbAMP DRAMP

Other

B1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
8-16 µM

Target

Staphylococcus haemolyticus

Source & Reference

dbAMP DRAMP

Other

C 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes N
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyog
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. x
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

L. monocytogenes NCTC 7973

Source & Reference

dbAMP DRAMP

Other

icus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedric
Evidence 9 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP DRAMP

Other

ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedrich et al., 2000 ).
Evidence 10 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

C. xerosis lab strain

Source & Reference

dbAMP DRAMP

Other

/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedrich et al., 2000 ).
Evidence 11 Activity

Activity

MIC
Antifungal
2-4 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active aga
Evidence 12 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

Escherichia coli UB1005

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923
Evidence 13 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. typhimurium 14028s

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemoly
Evidence 14 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Staphylococcus aureus ATCC 25923 or SAP0017 MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

B1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MI
Evidence 15 Activity

Activity

MIC
Antifungal
8-16 µM

Target

Staphylococcus haemolyticus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes N
Evidence 16 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyog
Evidence 17 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. x
Evidence 18 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

L. monocytogenes NCTC 7973

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

icus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedric
Evidence 19 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedrich et al., 2000 ).
Evidence 20 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

C. xerosis lab strain

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedrich et al., 2000 ).
Evidence 21 Activity

Activity

MIC
Antiparasitic
2-4 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active aga
Evidence 22 Activity

Activity

MIC
Antiparasitic
0.5 µg/mL

Target

Escherichia coli UB1005

Source & Reference

DRAMP

Other

active against P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923
Evidence 23 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

S. typhimurium 14028s

Source & Reference

DRAMP

Other

ainst P. aeruginosa PAO1 and mutants (MIC 2-4 ug/ml), E. coli UB1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemoly
Evidence 24 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Staphylococcus aureus ATCC 25923 or SAP0017 MRSA

Source & Reference

DRAMP

Other

B1005 (MIC 0.5 ug/ml), and S. typhimurium 14028s (MIC 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MI
Evidence 25 Activity

Activity

MIC
Antiparasitic
8-16 µM

Target

Staphylococcus haemolyticus

Source & Reference

DRAMP

Other

C 2 ug/ml). Also active against Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes N
Evidence 26 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Gram+ S. aureus ATCC 25923 or SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyog
Evidence 27 Activity

Activity

MIC
Antiparasitic
64 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

SAP0017 MRSA (MIC 8 ug/ml), S. haemolyticus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. x
Evidence 28 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

L. monocytogenes NCTC 7973

Source & Reference

DRAMP

Other

icus (MIC 8-16 uM), S. epidermidis (MIC 16 ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedric
Evidence 29 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Streptococcus pyogenes ATCC 19615

Source & Reference

DRAMP

Other

ug/ml), E. faecalis ATCC 29212 (MIC 64 ug/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedrich et al., 2000 ).
Evidence 30 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

C. xerosis lab strain

Source & Reference

DRAMP

Other

/ml), L. monocytogenes NCTC 7973 (MIC 4 ug/ml), S. pyogenes ATCC 19615 (MIC 8 ug/ml), and C. xerosis lab strain (MIC 2 ug/ml) ( Friedrich et al., 2000 ).
Evidence 31 Activity

Activity

0% Hemolysis
Toxicity
55 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 55 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Cationic Peptides | Patent US 6906035 B2 | 2005