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Peptide record

TPDB10828

Antibacterial Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10828
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
PPHKKKLAVYPVFLFYLFLSWFSLIV
Physicochemical Analysis
C164H238N32O31
RNDCEQGMT
L
3153.89
10.23
4
0
17
+3
-5.78
0.935
127.31
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
8480
268.87
4
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
5
L
3
K
0
M
4
F
3
P
2
S
0
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 5 K: 3 M: 0 F: 4 P: 3 S: 2 T: 0 W: 1 Y: 2 V: 3
Chemical Descriptors
26
C164H238N32O31
3153.89
10.23
+3
-5.78
0.935
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against A. hydrophila ATCC 35654 (killed 77% at 25 ug/ml), and Gram+ S. aureus ATCC 25923 (killed 42% at 25 ug/ml). It binds to LPS and LTA.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against A. hydrophila ATCC 35654 (killed 77% at 25 ug/ml), and Gram+ S. aureus ATCC 25923 (killed 42% at 25 ug/ml). It binds to LPS and LTA.
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional characterization of an uncharacterized antimicrobial peptide from a ciliate Paramecium caudatum. | Dev Comp Immunol | 2016
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.26883426] cPcAMP1/26 showed little hemolytic activity towards human erythrocytes at 100 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2016 Jul 60:53-65.