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Peptide record

TPDB10822

Antibacterial Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10822
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 26-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFLKTFKKAVKTVLHTALKAISS
Physicochemical Analysis
C141H234N36O33
RNDCEQGMPY
K
2961.63
11.29
8
0
12
+7
2.23
-0.023
93.85
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
185.71
6
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
3
L
7
K
0
M
2
F
0
P
3
S
3
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 7 M: 0 F: 2 P: 0 S: 3 T: 3 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C141H234N36O33
2961.63
11.29
+7
2.23
-0.023
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
4.0 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 4.0 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. | J Biol Chem | 2005
Evidence 2 Activity

Activity

MHC
Toxicity
4.0 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC=4.0 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.
Evidence 3 Activity

Activity

MHC
Toxicity
31.2 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC=31.2 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.