Back to search

Peptide record

TPDB10817

LAH4-L1 Antibacterial Antiparasitic Cell-penetrating Peptides Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10817
LAH4-L1
Antibacterial Antiparasitic Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia i2APP CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antiparasitic, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, i2APP, and other sources, with an available 3D structural model.
Sequence
KKALLAHALHLLALLALHLAHALKKA
Physicochemical Analysis
C132H228N38O27
RNDCEQGIMFPSTWYV
L
2779.50
11.00
8
0
18
+4
0.84
0.923
180.77
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
4
H
0
I
10
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 10 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C132H228N38O27
2779.50
11.00
+4
0.84
0.923
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 6 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Nucleic acid (siRNA)
Cytosol
In vitro
CCCTTSCCCHHHHHSCCSSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 and A549 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
Nucleic acid (Plasmid DNA and siRNA)
Cytoplasm
Clathrin independent endocytic pathways
In vitro
CCCTTSCCCHHHHHSCCSSSCC
Evidence 3 Activity

Activity

EC50
Toxicity
>92 µM
Cytotoxic
EC50 | >92 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 4 Activity

Activity

EC50
Toxicity
24.7 µM
Cytotoxic
EC50 | 24.7 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 5 Activity

Activity

EC50
Toxicity
>92 µM
Cytotoxic
EC50 | >92 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream. | Biochemistry | 2007
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Control Release. 2012 Mar 10 158(2):293-303.
Additional Detail Fields 1 fields
CCCTTSCCCHHHHHSCCSSSCC