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Peptide record

TPDB10816

Antibacterial Anticancer Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10816
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, HemoPI, and other sources, with an available 3D structural model.
Sequence
GLFGKLIKKKGRKAISYAVKKARGKH
Physicochemical Analysis
C133H232N42O29
NDCEQMPTW
K
2883.57
11.80
11
0
10
+10
6.42
-0.696
82.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
51.67
2
Residue Composition
number
3
A
2
R
0
N
0
D
0
C
0
E
0
Q
4
G
1
H
2
I
2
L
8
K
0
M
1
F
0
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 2 L: 2 K: 8 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
26
C133H232N42O29
2883.57
11.80
+10
6.42
-0.696
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>36 µM
Hemolytic Cytotoxic
50% Hemolysis | >36 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins. | FEBS Lett | 2009
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>36 µM
Cytotoxic
50% Cell death | >36 | µM | target cell: Human leukocytes

Target

Human leukocytes

Source & Reference

NA
DBAASP
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins. | FEBS Lett | 2009
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>36 µM | Cytotoxicity: Human leukocytes: 50% Cell death>36 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
FEBS Lett. 2009 Jul 21 583(14):2425-8.
Evidence 4 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis