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Peptide record

TPDB10813

Antibacterial Antifungal Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10813
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FLFSLIPSAISGLISAFKGRRKRDLN
Physicochemical Analysis
C134H220N38O34
CEQHMTWYV
LS
2907.45
12.13
5
1
12
+4
0.15
0.262
112.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
2
A
3
R
1
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
2
K
0
M
3
F
1
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 2 M: 0 F: 3 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26
C134H220N38O34
2907.45
12.13
+4
0.15
0.262
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.24 µM

Target

S. epidermidi P1111

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
1.85 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 4.87 uM), penicillin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2
Evidence 2 Activity

Activity

MIC
Antibacterial
3.01 µM

Target

Staphylococcus aureus p1369

Source & Reference

dbAMP

Other

lin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2.60 uM), penicillin-resistant S. epidermidis P1389 (LC 2.35 uM), MRSA p1
Evidence 3 Activity

Activity

MIC
Antifungal
4.24 µM

Target

S. epidermidi P1111

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
1.85 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 4.87 uM), penicillin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2
Evidence 4 Activity

Activity

MIC
Antifungal
3.01 µM

Target

Staphylococcus aureus p1369

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2.60 uM), penicillin-resistant S. epidermidis P1389 (LC 2.35 uM), MRSA p1
Evidence 5 Activity

Activity

66±1.2% Hemolysis
Toxicity
3.125 µM
Hemolytic Cytotoxic
66±1.2% Hemolysis | 3.125 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 7 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.