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Peptide record

TPDB10813

Antibacterial Antifungal Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10813
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 26-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FLFSLIPSAISGLISAFKGRRKRDLN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C134H220N38O34
CEQHMTWYV
LS
2907.45
12.13
5
1
12
+4
1.38
0.262
112.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
2
A
3
R
1
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
2
K
0
M
3
F
1
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 2 M: 0 F: 3 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
26 reviewed residue count
C134H220N38O34 sequence-only estimate (linear, free termini)
2907.45 sequence-only estimate (linear, free termini)
12.13 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
1.38 sequence-only estimate (linear, free termini)
0.262 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.24 µM

Target

S. epidermidi P1111

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
1.85 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 4.87 uM), penicillin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2
Evidence 2 Activity

Activity

MIC
Antibacterial
3.01 µM

Target

Staphylococcus aureus p1369

Source & Reference

dbAMP

Other

lin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2.60 uM), penicillin-resistant S. epidermidis P1389 (LC 2.35 uM), MRSA p1
Evidence 3 Activity

Activity

MIC
Antifungal
4.24 µM

Target

S. epidermidi P1111

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
1.85 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 4.87 uM), penicillin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2
Evidence 4 Activity

Activity

MIC
Antifungal
3.01 µM

Target

Staphylococcus aureus p1369

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lin-sensitive S. epidermidi P1111 (MIC 4.24 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 3.01 uM), MRSA P1374 (LC 2.60 uM), penicillin-resistant S. epidermidis P1389 (LC 2.35 uM), MRSA p1
Evidence 5 Activity

Activity

66±1.2% Hemolysis
Toxicity
3.125 µM
Hemolytic Cytotoxic
66±1.2% Hemolysis | 3.125 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 7 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.