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Peptide record

TPDB10810

Antibacterial Antifungal Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10810
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
ATYRTGRATRESLSGVEISGRLYRLR
Physicochemical Analysis
C126H214N44O39
NDCQHKMFPW
R
2969.36
11.73
6
2
9
+4
5.60
-0.715
78.85
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
100.36
8
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
2
E
0
Q
3
G
0
H
1
I
3
L
0
K
0
M
0
F
0
P
3
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 0 M: 0 F: 0 P: 0 S: 3 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
26
C126H214N44O39
2969.36
11.73
+4
5.60
-0.715
Evidence Records 5 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of human α-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs. | Peptides | 2015
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
50% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of human ?-defensin 5 and its linear analogs: N-terminal fatty acylation results in enhanced antimicrobial activity of the linear analogs. | Peptides | 2015
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26206286] 0% hemolysis at 100µM against human red blood cells | Cytotoxicity: [Ref.26206286] No cytotoxic information found.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2015 Sep 71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
23 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26206286] 23% hemolysis at 10 µM , 50% hemolysis at 20 µM , 75% hemolysis at 50 µM , 87.5% hemolysis at 100 µM against human red blood cells | Cytotoxicity: [Ref.26206286] No cytotoxic information found.

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2015 Sep 71:128-40. doi: 10.1016/j.peptides.2015.07.009. Epub 2015 Jul 20.
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis