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Peptide record

TPDB10802

Anti-inflammatory Antibacterial Antifungal Toxicity standard

26 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10802

Activity

Anti-inflammatory Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides

Database_Source

Peptipedia AntiBP3 Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, and Antifungipept, with an available 3D structural model.

Sequence

YYHFWHRGVTKRSLSPHRPRHSRLQR

FASTA

>TPDB10802|Anti-inflammatory;Antibacterial;Antifungal;Toxicity|length=26
YYHFWHRGVTKRSLSPHRPRHSRLQR

Formula C151H229N55O34

Absent Amino Acids ANDCEIM

Common Amino Acids R

Mass 3358.83

PI 12.41

Basic Residues 11

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +7

Boman Index 5.80

Hydrophobicity -1.646

Aliphatic Index 41.15

Half Life

Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min

Extinction Coefficient Cystines 8480

Absorbance 280nm 252.47

Polar Residues 7

number

Amino Acid Distribution

A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 4 I: 0 L: 2 K: 1 M: 0 F: 1 P: 2 S: 3 T: 1 W: 1 Y: 2 V: 1

Length

Formula

C151H229N55O34

Mass

3358.83

12.41

Net Charge

Boman Index

5.80

Hydrophobicity

-1.646

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism S. enterica

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (M

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

i (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

inosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source NA

Other

Evidence Text

erica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

iae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (M

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism S. enterica

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (M

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

i (MIC 2 uM), P. aeruginosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

inosa (MIC 4 uM) S. enterica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Streptococcus pyogenes

Source & Reference

Database Source Antifungipept

Other

Evidence Text

erica (MIC 4 uM) K. pneumoniae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

iae (MIC 2 uM) S. aureus (MIC 4 uM) B. subtilis (MIC 2 uM) S. pyogenes (MIC 4 uM) and E. faecalis (MIC 4 uM).

Evidence 17 Activity

Activity

Activity Endpoint <10% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

<10% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics. | ACS Omega | 2018

Evidence 18 Activity

Activity

Activity Endpoint 25% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Cytotoxic

Toxicity Raw

25% Killing | 100 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Target Cell Mouse fibroblasts NIH 3T3

Source & Reference

Database Source NA

Source Database DBAASP

Reference