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Peptide record

TPDB10800

Antibacterial Anticancer Antifungal Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10800
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
TRWLWLLRGGLKAAGWGIRAHLNRNQ
Physicochemical Analysis
C139H219N47O31
DCEMFPSYV
L
3044.56
12.88
6
0
12
+5
-2.38
-0.450
101.54
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
16500
541.95
4
Residue Composition
number
3
A
4
R
2
N
0
D
0
C
0
E
1
Q
4
G
1
H
1
I
5
L
1
K
0
M
0
F
0
P
0
S
1
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 2 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 1 I: 1 L: 5 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 3 Y: 0 V: 0
Chemical Descriptors
26
C139H219N47O31
3044.56
12.88
+5
-2.38
-0.450
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- bacteria E. coli, S. dysenteriae, K. pneumoniae, K. oxytoca, P. vulgaris, P. mirabilis, A. baumannii, S. maltophilia, and P. aeruginosa, and Gram+ bacteria S. aureus, B. cereus, E. faecium, and S. epidermidis. Also active against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. harveyi, V. parahaemdyticus, V. anguillarum, and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml, it showed 48% hemolysis (human red blood cells).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- bacteria E. coli, S. dysenteriae, K. pneumoniae, K. oxytoca, P. vulgaris, P. mirabilis, A. baumannii, S. maltophilia, and P. aeruginosa, and Gram+ bacteria S. aureus, B. cereus, E. faecium, and S. epidermidis. Also active against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. harveyi, V. parahaemdyticus, V. anguillarum, and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml, it showed 48% hemolysis (human red blood cells).
Evidence 3 Activity

Activity

89±1.2% Cell death
Toxicity
200 µg/mL
Cytotoxic
89±1.2% Cell death | 200 | µg/mL | target cell: Chinese hamster ovary cells CHO

Target

Chinese hamster ovary cells CHO

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 4 Activity

Activity

43±5.7% Cell death
Toxicity
200 µg/mL
Cytotoxic
43±5.7% Cell death | 200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 5 Activity

Activity

48±1.9% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
48±1.9% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017