TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10791

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

IWSFLIKAATKLLGVGSLFGGGKKDS

FASTA

>TPDB10791|Antibacterial;Antifungal;Hemolysis;Toxicity|length=26
IWSFLIKAATKLLGVGSLFGGGKKDS

Formula C127H205N31O33

Absent Amino Acids RNCEQHMPY

Common Amino Acids G

Mass 2694.21

PI 10.55

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 12

Net Charge +3

Boman Index -1.47

Hydrophobicity 0.481

Aliphatic Index 108.85

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 204.14

Polar Residues 4

number

2

A

0

R

0

N

1

D

0

C

0

E

0

Q

5

G

0

H

2

I

4

L

4

K

0

M

2

F

0

P

3

S

1

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 4 K: 4 M: 0 F: 2 P: 0 S: 3 T: 1 W: 1 Y: 0 V: 1

Length

26

Formula

C127H205N31O33

Mass

2694.21

PI

10.55

Net Charge

+3

Boman Index

-1.47

Hydrophobicity

0.481

Evidence 1 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 32 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. | Toxicon | 2016

Evidence 2 Activity

Activity

Activity Endpoint 22% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

22% Hemolysis | 64 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. | Toxicon | 2016

Evidence 3 Activity

Activity

Activity Endpoint 67% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

67% Hemolysis | 128 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. | Toxicon | 2016

Evidence 4 Activity

Activity

Activity Endpoint 90% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 512 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

90% Hemolysis | 512 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. | Toxicon | 2016

Evidence 5 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis