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Peptide record

TPDB10760

Antibacterial Antifungal Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10760
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 26-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RRGYGLKLALAKDGWALMLRLGFGRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C135H224N44O30S1
NCEQHIPSTV
L
2975.60
12.24
7
1
13
+6
1.82
-0.196
101.54
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
2.35
1
Residue Composition
number
3
A
5
R
0
N
1
D
0
C
0
E
0
Q
5
G
0
H
0
I
6
L
2
K
1
M
1
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 5 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 6 K: 2 M: 1 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
26 reviewed residue count
C135H224N44O30S1 sequence-only estimate (linear, free termini)
2975.60 sequence-only estimate (linear, free termini)
12.24 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.82 sequence-only estimate (linear, free termini)
-0.196 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

35% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
35% Hemolysis | 15 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. | Biochemistry | 2007
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
25% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. | Biochemistry | 2007
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis