Back to search

Peptide record

TPDB10759

Antibacterial Antifungal Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10759
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 26-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RRGGGLELALAKDGWALMLDLGAGRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C119H202N40O33S1
NCQHIFPSTYV
GL
2753.22
11.15
5
3
12
+2
1.63
-0.146
105.38
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
2.00
0
Residue Composition
number
4
A
4
R
0
N
2
D
0
C
1
E
0
Q
6
G
0
H
0
I
6
L
1
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 4 N: 0 D: 2 C: 0 E: 1 Q: 0 G: 6 H: 0 I: 0 L: 6 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
26 reviewed residue count
C119H202N40O33S1 sequence-only estimate (linear, free termini)
2753.22 sequence-only estimate (linear, free termini)
11.15 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.63 sequence-only estimate (linear, free termini)
-0.146 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

20% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
20% Hemolysis | 15 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. | Biochemistry | 2007
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
5% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. | Biochemistry | 2007
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis