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Peptide record

TPDB10737

Antibacterial Anticancer Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10737
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFLKTFKSALKTVLHTALKAISS
Physicochemical Analysis
C139H229N35O34
RNDCEQGMPY
K
2934.56
11.21
7
0
12
+6
0.74
0.081
97.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
187.42
7
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
4
L
6
K
0
M
2
F
0
P
4
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 4 K: 6 M: 0 F: 2 P: 0 S: 4 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C139H229N35O34
2934.56
11.21
+6
0.74
0.081
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
<5% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 2 Activity

Activity

50% Cell death
Toxicity
6.55 µM
Cytotoxic
50% Cell death | 6.55 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 3 Activity

Activity

MHC
Toxicity
7.8 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC=7.8 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.