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Peptide record

TPDB10728

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10728
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFLGILFHGVHHGRKKALHMNSERRS
Physicochemical Analysis
C132H210N46O32S1
DCQPTWY
GH
2985.47
12.13
9
1
9
+4
6.41
-0.573
75.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
1
E
0
Q
4
G
4
H
1
I
3
L
2
K
1
M
2
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 4 I: 1 L: 3 K: 2 M: 1 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
26
C132H210N46O32S1
2985.47
12.13
+4
6.41
-0.573
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

>10% Killing
Toxicity
25 µM
Cytotoxic
>10% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.