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Peptide record

TPDB10726

Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10726
Anti-inflammatory Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 dbAMP DRAMP AntiCP 2.0 iACP-DRLF Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
RVKRVWPLVIRTVIAGYNLYRAIKKK
Physicochemical Analysis
C148H250N44O31
DCEQHMFS
RKV
3141.89
12.01
8
0
14
+8
2.38
-0.069
127.31
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
269.90
4
Residue Composition
number
2
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
4
K
0
M
0
F
1
P
0
S
1
T
1
W
2
Y
4
V
Amino Acid Distribution
A: 2 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 4 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 2 V: 4
Chemical Descriptors
26
C148H250N44O31
3141.89
12.01
+8
2.38
-0.069
Evidence Records 27 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.40-0.80 µM

Target

S. typhimurium ATCC 14028 or 700408

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli ATCC 25922 or O157:H7 or PCN033 or RS218 (MIC 0.80-10 uM), S. typhimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L.
Evidence 2 Activity

Activity

MIC
Antibacterial
0.4 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP DRAMP

Other

PCN033 or RS218 (MIC 0.80-10 uM), S. typhimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
3.18 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

phimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300
Evidence 4 Activity

Activity

MIC
Antibacterial
0.80 µM

Target

L. monocytogenes ATCC 19115

Source & Reference

dbAMP DRAMP

Other

uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300 MRSA (MIC 0.40-0.8 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
0.40-0.8 µM

Target

Staphylococcus aureus ATCC 25923 or BAA-39 or 43300 MRSA

Source & Reference

dbAMP DRAMP

Other

P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300 MRSA (MIC 0.40-0.8 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
0.40-0.80 µM

Target

S. typhimurium ATCC 14028 or 700408

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli ATCC 25922 or O157:H7 or PCN033 or RS218 (MIC 0.80-10 uM), S. typhimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L.
Evidence 7 Activity

Activity

MIC
Antifungal
0.4 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP DRAMP Antifungipept

Other

PCN033 or RS218 (MIC 0.80-10 uM), S. typhimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM),
Evidence 8 Activity

Activity

MIC
Antifungal
3.18 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP Antifungipept

Other

phimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300
Evidence 9 Activity

Activity

MIC
Antifungal
0.80 µM

Target

L. monocytogenes ATCC 19115

Source & Reference

dbAMP DRAMP Antifungipept

Other

uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300 MRSA (MIC 0.40-0.8 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
0.40-0.8 µM

Target

Staphylococcus aureus ATCC 25923 or BAA-39 or 43300 MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300 MRSA (MIC 0.40-0.8 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
0.40-0.80 µM

Target

S. typhimurium ATCC 14028 or 700408

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli ATCC 25922 or O157:H7 or PCN033 or RS218 (MIC 0.80-10 uM), S. typhimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L.
Evidence 12 Activity

Activity

MIC
Antiparasitic
0.4 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

DRAMP

Other

PCN033 or RS218 (MIC 0.80-10 uM), S. typhimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM),
Evidence 13 Activity

Activity

MIC
Antiparasitic
3.18 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

phimurium ATCC 14028 or 700408 (MIC 0.40-0.80 uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.80 µM

Target

L. monocytogenes ATCC 19115

Source & Reference

DRAMP

Other

uM), K. pneumoniae ATCC 13883 (MIC 0.4 uM), P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300 MRSA (MIC 0.40-0.8 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
0.40-0.8 µM

Target

Staphylococcus aureus ATCC 25923 or BAA-39 or 43300 MRSA

Source & Reference

DRAMP

Other

P. aeruginosa ATCC 27853 (MIC 3.18 uM), Gram+ L. monocytogenes ATCC 19115 (MIC 0.80 uM), S. aureus ATCC 25923 or BAA-39 or 43300 MRSA (MIC 0.40-0.8 uM).
Evidence 16 Activity

Activity

% Hemolysis
Hemolysis
80 %
[Ref.16326712]80% hemolytic activity at 10 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biol Chem. 2006 Feb 3 281(5):2858-2867.##FEBS J. 2006 Jun 273(12):2581-2593.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 17 Activity

Activity

50% Hemolysis
Toxicity
6 µM
Hemolytic Cytotoxic
50% Hemolysis | 6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken | FASEB J | 2006
Evidence 18 Activity

Activity

50% Cell death
Toxicity
15 µM
Cytotoxic
50% Cell death | 15 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken | FASEB J | 2006
Evidence 19 Activity

Activity

15.6% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
15.6% Hemolysis | 4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20 | Bull Korean Chem Soc | 2019
Evidence 20 Activity

Activity

23.1% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
23.1% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20 | Bull Korean Chem Soc | 2019
Evidence 21 Activity

Activity

33.1% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
33.1% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20 | Bull Korean Chem Soc | 2019
Evidence 22 Activity

Activity

43.6% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
43.6% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20 | Bull Korean Chem Soc | 2019
Evidence 23 Activity

Activity

74.3% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
74.3% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20 | Bull Korean Chem Soc | 2019
Evidence 24 Activity

Activity

87.4% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
87.4% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Improving Cell Selectivity of Fowlicidin-1 by Swapping Residues between Pro-7 and Tyr-20 | Bull Korean Chem Soc | 2019
Evidence 25 Activity

Activity

10% Hemolysis
Toxicity
38 µM
Hemolytic Cytotoxic
10% Hemolysis | 38 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities. | Eur J Med Chem | 2019
Evidence 26 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16326712]80% hemolytic activity at 10 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biol Chem. 2006 Feb 3 281(5):2858-2867.##FEBS J. 2006 Jun 273(12):2581-2593.
Evidence 27 Hemolysis

Activity

80 %
% Hemolysis
[Ref.16326712]80% hemolytic activity at 10 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biol Chem. 2006 Feb 3 281(5):2858-2867.##FEBS J. 2006 Jun 273(12):2581-2593.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.