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Peptide record

TPDB10725

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10725
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP pep-lab Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIGIGAVLKVLTTGLPALIS
Physicochemical Analysis
C136H232N32O30
RNDCEQHMY
LK
2795.53
11.12
5
0
14
+5
-1.07
0.842
150.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
196.74
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
3
I
5
L
5
K
0
M
1
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 3 L: 5 K: 5 M: 0 F: 1 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C136H232N32O30
2795.53
11.12
+5
-1.07
0.842
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-16 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants or H103 or K799

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against P. aeruginosa PAO1 and mutants or H103 or K799 (MIC 2-16 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (
Evidence 2 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

S. typhimurium 14028sor MS7953s

Source & Reference

dbAMP DRAMP

Other

or H103 or K799 (MIC 2-16 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia AT
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Enterobacter cloacae 218S

Source & Reference

dbAMP DRAMP

Other

or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calc
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP DRAMP

Other

/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. a
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

X. maltophilia ATCC 13637

Source & Reference

dbAMP DRAMP

Other

s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). i
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

A. calcoaceticus 8193

Source & Reference

dbAMP DRAMP

Other

ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). including resistance strains A. bauman
Evidence 7 Activity

Activity

MIC
Antibacterial
2-8 µg/mL

Target

A. baumannii

Source & Reference

dbAMP DRAMP

Other

2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). including resistance strains A. baumannii (MIC 2-8 ug/ml) ( Rodríguez-Hernández et al., 2006 ). Binds LPS:anti-inflammatory by reducing TNF-alpha r
Evidence 8 Activity

Activity

MIC
Antifungal
2-16 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants or H103 or K799

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against P. aeruginosa PAO1 and mutants or H103 or K799 (MIC 2-16 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (
Evidence 9 Activity

Activity

MIC
Antifungal
2-4 µg/mL

Target

S. typhimurium 14028sor MS7953s

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

or H103 or K799 (MIC 2-16 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia AT
Evidence 10 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Enterobacter cloacae 218S

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calc
Evidence 11 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. a
Evidence 12 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

X. maltophilia ATCC 13637

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). i
Evidence 13 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

A. calcoaceticus 8193

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). including resistance strains A. bauman
Evidence 14 Activity

Activity

MIC
Antifungal
2-8 µg/mL

Target

A. baumannii

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). including resistance strains A. baumannii (MIC 2-8 ug/ml) ( Rodríguez-Hernández et al., 2006 ). Binds LPS:anti-inflammatory by reducing TNF-alpha r
Evidence 15 Activity

Activity

MIC
Antiparasitic
2-16 µg/mL

Target

Pseudomonas aeruginosa PAO1 and mutants or H103 or K799

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
active against P. aeruginosa PAO1 and mutants or H103 or K799 (MIC 2-16 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (
Evidence 16 Activity

Activity

MIC
Antiparasitic
2-4 µg/mL

Target

S. typhimurium 14028sor MS7953s

Source & Reference

dbAMP 3.0 DRAMP

Other

or H103 or K799 (MIC 2-16 ug/ml), E. coli UB1005 or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia AT
Evidence 17 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Enterobacter cloacae 218S

Source & Reference

dbAMP 3.0 DRAMP

Other

or Bort or O111:B4 (MIC 1-6 ug/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calc
Evidence 18 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP 3.0 DRAMP

Other

/ml), and S. typhimurium 14028sor MS7953s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. a
Evidence 19 Activity

Activity

MIC
Antiparasitic
8 µg/mL

Target

X. maltophilia ATCC 13637

Source & Reference

dbAMP 3.0 DRAMP

Other

s (MIC 2-4 ug/ml). E. cloacae 218S (MIC 4 ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). i
Evidence 20 Activity

Activity

MIC
Antiparasitic
2 µg/mL

Target

A. calcoaceticus 8193

Source & Reference

dbAMP 3.0 DRAMP

Other

ug/ml), K. pneumoniae ATCC 13883 (MIC 8 ug/ml), X. maltophilia ATCC 13637 (MIC 8 ug/ml), A. calcoaceticus 8193 (MIC 2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). including resistance strains A. bauman
Evidence 21 Activity

Activity

MIC
Antiparasitic
2-8 µg/mL

Target

A. baumannii

Source & Reference

dbAMP 3.0 DRAMP

Other

2 ug/ml). Also, S. aureus (LC 1 uM), S. pyogenes (LC 2 uM). including resistance strains A. baumannii (MIC 2-8 ug/ml) ( Rodríguez-Hernández et al., 2006 ). Binds LPS:anti-inflammatory by reducing TNF-alpha r
Evidence 22 Activity

Activity

100% Hemolysis
Toxicity
>600 µM
Hemolytic Cytotoxic
100% Hemolysis | >600 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
The plasma membrane of Leishmania donovani promastigotes is the main target for CA(1-8)M(1-18), a synthetic cecropin A-melittin hybrid peptide. | Biochem J | 1998