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Peptide record

TPDB10719

Antibacterial Anticancer Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10719
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWKSFLKTFKSAEKTVLHTALKAISS
Physicochemical Analysis
C138H225N35O36
RNDCQGMPY
K
2950.52
10.82
7
1
11
+5
3.32
-0.200
82.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
186.41
7
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
1
H
1
I
3
L
6
K
0
M
2
F
0
P
4
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 6 M: 0 F: 2 P: 0 S: 4 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C138H225N35O36
2950.52
10.82
+5
3.32
-0.200
Evidence Records 3 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
<5% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>125 µM
Cytotoxic
50% Cell death | >125 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:<5% Hemolysis=>500µM | Cytotoxicity: 3T3-L1:50% Cell death>125µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2016 Jul 1 6:29145.