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Peptide record

TPDB10708

Antibacterial Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB10708
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 26-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKSFLKTFKSASKTVLHTALKAISS
Physicochemical Analysis
C136H223N35O35
RNDCEQGMPY
K
2908.48
11.21
7
0
11
+6
1.43
-0.096
82.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
189.10
8
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
3
L
6
K
0
M
2
F
0
P
5
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 6 M: 0 F: 2 P: 0 S: 5 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
26
C136H223N35O35
2908.48
11.21
+6
1.43
-0.096
Evidence Records 4 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
125.0 µM
Hemolytic Cytotoxic
<5% Hemolysis | 125.0 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 2 Activity

Activity

50% Cell death
Toxicity
17 µM
Cytotoxic
50% Cell death | 17 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Specificity and mechanism of action of alpha-helical membrane-active peptides interacting with model and biological membranes by single-molecule force spectroscopy. | Sci Rep | 2016
Evidence 3 Activity

Activity

MHC
Toxicity
125.0 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC=125.0 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.
Evidence 4 Activity

Activity

MHC
Toxicity
250.0 µg/mL
Hemolytic
Hemolytic_activity: [Ref.15677462]MHC>250.0 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2005 Apr 1 280(13):12316-29.