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Peptide record

TPDB10699

Antibacterial Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10699
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
AGRQALTKYLLEELRKRWKKAFIAW
Physicochemical Analysis
C145H231N41O33
NDCHMPSV
ALK
3076.68
11.00
7
2
13
+5
2.16
-0.564
94.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
405.96
3
Residue Composition
number
4
A
3
R
0
N
0
D
0
C
2
E
1
Q
1
G
0
H
1
I
4
L
4
K
0
M
1
F
0
P
0
S
1
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 0
Chemical Descriptors
25
C145H231N41O33
3076.68
11.00
+5
2.16
-0.564
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Antibacterial
0.47 µM

Target

L. donovani

Source & Reference

NA

Other

exhibits leishmanicidal activity against L. donovani (IC50 0.47 uM).
Evidence 2 Activity

Activity

10.5% Hemolysis
Toxicity
>16 µM
Hemolytic Cytotoxic
10.5% Hemolysis | >16 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Synthetic Peptide Libraries Designed From a Minimal Alpha-Helical Domain of AS-48-Bacteriocin Homologs Exhibit Potent Antibacterial Activity. | Front Microbiol | 2020
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis