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Peptide record

TPDB10686

Antibacterial Antifungal Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10686
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GFSSLFKAGAKYLLKQVGKAGAQQL
Physicochemical Analysis
C121H196N32O32
RNDCEHIMPTW
AGLK
2611.08
10.64
4
0
12
+4
-0.05
0.064
90.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
57.06
6
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
3
Q
4
G
0
H
0
I
4
L
4
K
0
M
2
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 4 H: 0 I: 0 L: 4 K: 4 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C121H196N32O32
2611.08
10.64
+4
-0.05
0.064
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Interestingly, this 25-residue peptide gained both activity and cell selectivity. Broadly active against Gram+, Gram-, and fungi such as S. aureus, E. faecalis, MRSA, E. coli, P. aeruginosa, K. pneumoniae, and C. albicans.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Interestingly, this 25-residue peptide gained both activity and cell selectivity. Broadly active against Gram+, Gram-, and fungi such as S. aureus, E. faecalis, MRSA, E. coli, P. aeruginosa, K. pneumoniae, and C. albicans.
Evidence 3 Activity

Activity

18% Killing
Toxicity
100 µM
Cytotoxic
18% Killing | 100 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Brevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity | Antibiotics (Basel) | 2020
Evidence 4 Activity

Activity

8% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
8% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Brevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity | Antibiotics (Basel) | 2020