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Peptide record

TPDB10683

Antibacterial Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10683
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
AGKETIRQYLKNEIKKKGRKAVIAW
Physicochemical Analysis
C133H226N40O34
DCHMFPS
K
2929.51
10.85
8
2
10
+6
8.04
-0.928
86.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
6990
238.61
4
Residue Composition
number
3
A
2
R
1
N
0
D
0
C
2
E
1
Q
2
G
0
H
3
I
1
L
6
K
0
M
0
F
0
P
0
S
1
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 1 G: 2 H: 0 I: 3 L: 1 K: 6 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 1
Chemical Descriptors
25
C133H226N40O34
2929.51
10.85
+6
8.04
-0.928
Evidence Records 3 records
Evidence 1 Activity

Activity

30% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
30% Cytotoxicity | 64 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020
Evidence 2 Activity

Activity

15% Cytotoxicity
Toxicity
32 µg/mL
Cytotoxic
15% Cytotoxicity | 32 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020
Evidence 3 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy. | ACS Pharmacol Transl Sci | 2020