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Peptide record

TPDB10673

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

25 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10673

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 APD_complete PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FIFHIIKGLFHAGKMIHGLVTRRRH

FASTA

>TPDB10673|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=25
FIFHIIKGLFHAGKMIHGLVTRRRH

Formula C140H222N44O27S1

Absent Amino Acids NDCEQPSWY

Common Amino Acids HI

Mass 2985.64

PI 12.71

Basic Residues 9

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +5

Boman Index 2.34

Hydrophobicity 0.236

Aliphatic Index 109.20

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 4 I: 4 L: 2 K: 2 M: 1 F: 3 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

Formula

C140H222N44O27S1

Mass

2985.64

12.71

Net Charge

Boman Index

2.34

Hydrophobicity

0.236

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.25 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.25 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.25 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2.5 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.25 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.25 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli (MIC 2.5 uM), S. aureus (MIC 1.25 uM), and V. parahaemolyticus (MIC 1.25 uM). MBC values are the same same MICs.

Evidence 13 Activity

Activity

Activity Endpoint 20% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

20% Hemolysis | 20 | µM | target cell: Fish erythrocytes

Target

Target Cell Fish erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016

Evidence 14 Activity

Activity

Activity Endpoint 75% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 20 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

75% Hemolysis | 20 | µM | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Two isoforms of piscidin from Malabar grouper, Epinephelus malabaricus: Expression and functional characterization. | Fish Shellfish Immunol | 2016

Evidence 15 Hemolysis

Source & Reference

source APD_complete PD_Hemolysis

Database Source APD_complete PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation.