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Peptide record

TPDB10669

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10669
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia SATPdb Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GWKKWFNRAKKVGKTVGGLAVDHYL
Physicochemical Analysis
C135H208N38O31
CEQIMPS
K
2859.37
10.76
7
1
11
+5
1.53
-0.520
74.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
436.81
3
Residue Composition
number
2
A
1
R
1
N
1
D
0
C
0
E
0
Q
4
G
1
H
0
I
2
L
5
K
0
M
1
F
0
P
0
S
1
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 1 I: 0 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 3
Chemical Descriptors
25
C135H208N38O31
2859.37
10.76
+5
1.53
-0.520
Evidence Records 49 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

dbAMP

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM)
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

dbAMP

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E.
Evidence 6 Activity

Activity

MIC
Antibacterial
1 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

dbAMP

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epide
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli CGSC4908

Source & Reference

dbAMP

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methi
Evidence 8 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli UB1005

Source & Reference

dbAMP

Other

P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus
Evidence 9 Activity

Activity

MIC
Antibacterial
2 µM

Target

Escherichia coli DC2

Source & Reference

dbAMP

Other

M), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM),
Evidence 10 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP

Other

IC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Up
Evidence 11 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans C627

Source & Reference

dbAMP

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Updated 7/2021
Evidence 12 Activity

Activity

MIC
Antifungal
2 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 13 Activity

Activity

MIC
Antifungal
2 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 14 Activity

Activity

MIC
Antifungal
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 15 Activity

Activity

MIC
Antifungal
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM)
Evidence 16 Activity

Activity

MIC
Antifungal
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

dbAMP CAFPdb Antifungipept

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E.
Evidence 17 Activity

Activity

MIC
Antifungal
1 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epide
Evidence 18 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli CGSC4908

Source & Reference

dbAMP CAFPdb Antifungipept

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methi
Evidence 19 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli UB1005

Source & Reference

dbAMP CAFPdb Antifungipept

Other

P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus
Evidence 20 Activity

Activity

MIC
Antifungal
2 µM

Target

Escherichia coli DC2

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM),
Evidence 21 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP CAFPdb Antifungipept

Other

IC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Up
Evidence 22 Activity

Activity

MIC
Antifungal
4 µM

Target

Candida albicans C627

Source & Reference

dbAMP CAFPdb Antifungipept

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Updated 7/2021
Evidence 23 Activity

Activity

MIC
Antiparasitic
2 µM

Target

A. salmonicida 99-1

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 24 Activity

Activity

MIC
Antiparasitic
2 µM

Target

A. salmonicida 97-4

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 25 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 26 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

NA

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM)
Evidence 27 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

NA

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E.
Evidence 28 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

NA

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epide
Evidence 29 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Escherichia coli CGSC4908

Source & Reference

NA

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methi
Evidence 30 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Escherichia coli UB1005

Source & Reference

NA

Other

P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus
Evidence 31 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Escherichia coli DC2

Source & Reference

NA

Other

M), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM),
Evidence 32 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

NA

Other

IC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Up
Evidence 33 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Candida albicans C627

Source & Reference

NA

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Updated 7/2021
Evidence 34 Activity

Activity

MIC
Antiviral
2 µM

Target

A. salmonicida 99-1

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 35 Activity

Activity

MIC
Antiviral
2 µM

Target

A. salmonicida 97-4

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 36 Activity

Activity

MIC
Antiviral
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

NA

Other

Active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 37 Activity

Activity

MIC
Antiviral
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

NA

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM)
Evidence 38 Activity

Activity

MIC
Antiviral
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

NA

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E.
Evidence 39 Activity

Activity

MIC
Antiviral
1 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

NA

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epide
Evidence 40 Activity

Activity

MIC
Antiviral
2 µM

Target

Escherichia coli CGSC4908

Source & Reference

NA

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methi
Evidence 41 Activity

Activity

MIC
Antiviral
8 µM

Target

Escherichia coli UB1005

Source & Reference

NA

Other

P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus
Evidence 42 Activity

Activity

MIC
Antiviral
2 µM

Target

Escherichia coli DC2

Source & Reference

NA

Other

M), P. aeruginosa Z61 (MIC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM),
Evidence 43 Activity

Activity

MIC
Antiviral
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

NA

Other

IC 1 uM), E. coli CGSC4908 (MIC 2 uM), E. coli UB1005 (MIC 8 uM), E. coli DC2 (MIC 2 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Up
Evidence 44 Activity

Activity

MIC
Antiviral
4 µM

Target

Candida albicans C627

Source & Reference

NA

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus (MRSA) C623 (MIC 16 uM), C. albicans C627 (MIC 4 uM). Updated 7/2021
Evidence 45 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 46 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 47 Activity

Activity

>10% Killing
Toxicity
25 µM
Cytotoxic
>10% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 48 Activity

Activity

100% Killing
Toxicity
5 µM
Cytotoxic
100% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 49 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.