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Peptide record

TPDB10666

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10666
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept dbAMP 3.0 i2APP ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLWSTIKNVGKEAAIAAGKAALGAL
Physicochemical Analysis
C109H184N30O31
RDCQHMFPY
A
2410.84
10.32
3
1
14
+2
0.45
0.580
117.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
228.14
3
Residue Composition
number
7
A
0
R
1
N
0
D
0
C
1
E
0
Q
4
G
0
H
2
I
3
L
3
K
0
M
0
F
0
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 2 L: 3 K: 3 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
25
C109H184N30O31
2410.84
10.32
+2
0.45
0.580
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
26.5 µM

Target

Staphylococcus aureus ATCC 43300 MRSA

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC 43300 MRSA (MIC 26.5 uM) and P. aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (para
Evidence 2 Activity

Activity

MIC
Antibacterial
6.6 µM

Target

Pseudomonas aeruginosa wt MR

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC 43300 MRSA (MIC 26.5 uM) and P. aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (parasite). T. cruzi (IC50 0.68 uM).
Evidence 3 Activity

Activity

IC50
Antibacterial
0.68 µM

Target

T. cruzi

Source & Reference

dbAMP DRAMP

Other

aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (parasite). T. cruzi (IC50 0.68 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
26.5 µM

Target

Staphylococcus aureus ATCC 43300 MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC 43300 MRSA (MIC 26.5 uM) and P. aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (para
Evidence 5 Activity

Activity

MIC
Antifungal
6.6 µM

Target

Pseudomonas aeruginosa wt MR

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against S. aureus ATCC 43300 MRSA (MIC 26.5 uM) and P. aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (parasite). T. cruzi (IC50 0.68 uM).
Evidence 6 Activity

Activity

IC50
Antifungal
0.68 µM

Target

T. cruzi

Source & Reference

dbAMP DRAMP Antifungipept

Other

aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (parasite). T. cruzi (IC50 0.68 uM).
Evidence 7 Activity

Activity

MIC
Antiparasitic
26.5 µM

Target

Staphylococcus aureus ATCC 43300 MRSA

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus ATCC 43300 MRSA (MIC 26.5 uM) and P. aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (para
Evidence 8 Activity

Activity

MIC
Antiparasitic
6.6 µM

Target

Pseudomonas aeruginosa wt MR

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus ATCC 43300 MRSA (MIC 26.5 uM) and P. aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (parasite). T. cruzi (IC50 0.68 uM).
Evidence 9 Activity

Activity

IC50
Antiparasitic
0.68 µM

Target

T. cruzi

Source & Reference

dbAMP 3.0 DRAMP

Other

aeruginosa wt MR (MIC 6.6 uM). Parasites: Also active against L. amazonensis (parasite). T. cruzi (IC50 0.68 uM).
Evidence 10 Activity

Activity

0% Hemolysis
Toxicity
6 µM
Hemolytic Cytotoxic
0% Hemolysis | 6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Isolation and biochemical characterization of peptides presenting antimicrobial activity from the skin of Phyllomedusa hypochondrialis | Peptides | 2006
Evidence 11 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human leukocytes

Target

Human leukocytes

Source & Reference

NA
DBAASP
Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia). | Biochem Biophys Res Commun | 2006
Evidence 12 Activity

Activity

50% Cytotoxicity
Toxicity
>20 µM
Cytotoxic
50% Cytotoxicity | >20 | µM | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Antimicrobial peptides isolated from Phyllomedusa nordestina (Amphibia) alter the permeability of plasma membrane of Leishmania and Trypanosoma cruzi. | Exp Parasitol | 2013
Evidence 13 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:16844081]Non-hemolytic activity upto 53 µM against human red blood cells ##[Ref.16963159]Non-hemolytic activity at 6 µM against erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2006 Sep 1 347(3):739-746.##Peptides. 2006 Dec 27(12):3092-3099.