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Peptide record

TPDB10665

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10665
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
SMWSGMWRRKLKKLRNALKKKLKGE
Physicochemical Analysis
C138H238N44O31S2
DCQHIFPTYV
K
3073.80
12.19
10
1
9
+9
5.51
-1.248
66.40
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11000
357.86
3
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
4
L
7
K
2
M
0
F
0
P
2
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 7 M: 2 F: 0 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
25
C138H238N44O31S2
3073.80
12.19
+9
5.51
-1.248
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.7-1 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P
Evidence 2 Activity

Activity

MIC
Antibacterial
4.1 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Viru
Evidence 3 Activity

Activity

MIC
Antibacterial
0.5-1.0 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

i DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3
Evidence 4 Activity

Activity

MIC
Antibacterial
17 µM

Target

P. pastoris

Source & Reference

dbAMP DRAMP

Other

), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3pro and virus replication in the
Evidence 5 Activity

Activity

MIC
Antifungal
0.7-1 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P
Evidence 6 Activity

Activity

MIC
Antifungal
4.1 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Viru
Evidence 7 Activity

Activity

MIC
Antifungal
0.5-1.0 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

i DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3
Evidence 8 Activity

Activity

MIC
Antifungal
17 µM

Target

P. pastoris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3pro and virus replication in the
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.7-1 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P
Evidence 10 Activity

Activity

MIC
Antiparasitic
4.1 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Viru
Evidence 11 Activity

Activity

MIC
Antiparasitic
0.5-1.0 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

i DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3
Evidence 12 Activity

Activity

MIC
Antiparasitic
17 µM

Target

P. pastoris

Source & Reference

dbAMP 3.0 DRAMP

Other

), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3pro and virus replication in the
Evidence 13 Activity

Activity

MIC
Antiviral
0.7-1 µM

Target

Escherichia coli DH1

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P
Evidence 14 Activity

Activity

MIC
Antiviral
4.1 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Active against Gram- E. coli DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Viru
Evidence 15 Activity

Activity

MIC
Antiviral
0.5-1.0 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

i DH5alpha, E. coli DH1 (MIC 0.7-1 uM), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3
Evidence 16 Activity

Activity

MIC
Antiviral
17 µM

Target

P. pastoris

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

), P. aeruginosa (MIC 4.1 uM), Gram+ A. globiformis, B. subtilis (MIC 0.5-1.0 uM), yeasts P. pastoris (MIC 17 uM). Virus: The peptide is also inhibitory to dengue NS2B-NS3pro and virus replication in the
Evidence 17 Activity

Activity

% Hemolysis
Hemolysis
20 %
[Ref.16735513]20% hemolytic activity at 80 µM against rabbit erythrocytes

Target

rabbit erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Biol Chem. 2006 Jul 28 281(30):20983-20992.##Biochemistry. 2008 Mar 18 47(11):3525-3533.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 18 Activity

Activity

20% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
20% Hemolysis | 80 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. | J Biol Chem | 2006
Evidence 19 Activity

Activity

36% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
36% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom | Int J Mol Sci | 2021
Evidence 20 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16735513]20% hemolytic activity at 80 µM against rabbit erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2006 Jul 28 281(30):20983-20992.##Biochemistry. 2008 Mar 18 47(11):3525-3533.
Evidence 21 Hemolysis

Activity

20 %
% Hemolysis
[Ref.16735513]20% hemolytic activity at 80 µM against rabbit erythrocytes
Hemolysis

Target

rabbit erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Biol Chem. 2006 Jul 28 281(30):20983-20992.##Biochemistry. 2008 Mar 18 47(11):3525-3533.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.