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Peptide record

TPDB10664

NRC-07 Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10664
NRC-07
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWGKWFKKATHVGKHVGKAALTAYL
Physicochemical Analysis
C136H209N39O29
NDCEQIMPS
K
2854.40
11.14
8
0
12
+6
0.56
-0.404
70.40
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
437.57
3
Residue Composition
number
4
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
2
H
0
I
2
L
5
K
0
M
1
F
0
P
0
S
2
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 2 I: 0 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 2 W: 2 Y: 1 V: 2
Chemical Descriptors
25
C136H209N39O29
2854.40
11.14
+6
0.56
-0.404
Free
L
Linear
Free
Anticancer
Synthetic
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP DRAMP

Other

Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP DRAMP

Other

Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

dbAMP DRAMP

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

dbAMP DRAMP

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermid
Evidence 6 Activity

Activity

MIC
Antibacterial
2 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

dbAMP DRAMP

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), a
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP DRAMP

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus epidermidis C621 or MRSA

Source & Reference

dbAMP DRAMP

Other

9 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 9 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans C627

Source & Reference

dbAMP DRAMP

Other

. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 10 Activity

Activity

14.0 ± 3.0% cell viability at 150 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2024

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 11 Activity

Activity

52.5 ± 5.0% cell viability at 150 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2024
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 13 Activity

Activity

MIC
Antifungal
2 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 14 Activity

Activity

MIC
Antifungal
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 15 Activity

Activity

MIC
Antifungal
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005
Evidence 16 Activity

Activity

MIC
Antifungal
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermid
Evidence 17 Activity

Activity

MIC
Antifungal
2 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), a
Evidence 18 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 19 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus epidermidis C621 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

9 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 20 Activity

Activity

MIC
Antifungal
16 µM

Target

Candida albicans C627

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 21 Activity

Activity

MIC
Antiparasitic
4 µM

Target

A. salmonicida 99-1

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. e
Evidence 22 Activity

Activity

MIC
Antiparasitic
2 µM

Target

A. salmonicida 97-4

Source & Reference

DRAMP

Other

Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 1402
Evidence 23 Activity

Activity

MIC
Antiparasitic
2 µM

Target

S. enterica serovar Typhimurium MS7953s

Source & Reference

DRAMP

Other

Active against A. salmonicida 99-1 (MIC 4 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aer
Evidence 24 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. enterica serovar Typhimurium 14028s

Source & Reference

DRAMP

Other

uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005
Evidence 25 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Pseudomonas aeruginosa K799

Source & Reference

DRAMP

Other

erovar Typhimurium MS7953s (MIC 2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermid
Evidence 26 Activity

Activity

MIC
Antiparasitic
2 µM

Target

Pseudomonas aeruginosa Z61

Source & Reference

DRAMP

Other

2 uM), S. enterica serovar Typhimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), a
Evidence 27 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

DRAMP

Other

phimurium 14028s (MIC 8 uM), P. aeruginosa K799 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 28 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Staphylococcus epidermidis C621 or MRSA

Source & Reference

DRAMP

Other

9 (MIC 4 uM), P. aeruginosa Z61 (MIC 2 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 29 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Candida albicans C627

Source & Reference

DRAMP

Other

. coli CGSC4908 or UB1005 or DC2 (MIC 4 uM), S. epidermidis C621 or MRSA (MIC 64 uM), and C. albicans C627 (MIC 16 uM).
Evidence 30 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 31 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 32 Activity

Activity

100% Killing
Toxicity
5 µM
Cytotoxic
100% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011