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Peptide record

TPDB10663

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10663
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWGSIFKHGRHAAKHIGHAAVNHYL
Physicochemical Analysis
C127H186N42O29
DCEQMPT
H
2765.14
10.72
8
0
11
+3
2.47
-0.376
74.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
252.79
3
Residue Composition
number
4
A
1
R
1
N
0
D
0
C
0
E
0
Q
4
G
5
H
2
I
1
L
2
K
0
M
1
F
0
P
1
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 5 I: 2 L: 1 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
25
C127H186N42O29
2765.14
10.72
+3
2.47
-0.376
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

100% Killing
Toxicity
25 µM
Cytotoxic
100% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 4 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.