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Peptide record

TPDB10660

LL-37(13-37) Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10660
LL-37(13-37)
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF Antifungipept
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
IGKEFKRIVQRIKDFLRNLVPRTES
Physicochemical Analysis
C137H232N42O36
ACHMWY
R
3043.61
11.39
7
3
9
+4
9.04
-0.624
101.20
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
4
R
1
N
1
D
0
C
2
E
1
Q
1
G
0
H
3
I
2
L
3
K
0
M
2
F
1
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 1 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 2 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
25
C137H232N42O36
3043.61
11.39
+4
9.04
-0.624
Free
L
Linear
Free
Antibacterial
LL-37,a series of peptide fragments
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli and S. aureus.
Evidence 2 Activity

Activity

LC50
LC50=39 µM
Anticancer
39 µM

Target

Tumor
KBv
Not Available

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

LC50
LC50=40 µM
Anticancer
40 µM

Target

Oral Cancer
KB
Not Available

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006
Evidence 4 Activity

Activity

LC50
LC50=38 µM
Anticancer
38 µM

Target

Prostate Cancer
HBMEC
Not Available

Assay & Model

MTT/MTS assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2006
Evidence 5 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli and S. aureus.
Evidence 6 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against E. coli and S. aureus.
Evidence 7 Activity

Activity

50% Cell death
Toxicity
38±3 µM
Cytotoxic
50% Cell death | 38±3 | µM | target cell: Human brain microvascular endothelial cells HBMEC

Target

Human brain microvascular endothelial cells HBMEC

Source & Reference

NA
DBAASP
Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. | J Am Chem Soc | 2006