Back to search

Peptide record

TPDB10659

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10659
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb dbAMP 3.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GVWSTVLGGLKKFAKGGLEAIVNPK
Physicochemical Analysis
C120H197N31O31
RDCQHMY
G
2570.07
10.55
4
1
11
+3
2.07
0.252
105.20
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
214.00
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
5
G
0
H
1
I
3
L
4
K
0
M
1
F
1
P
1
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 3 K: 4 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
25
C120H197N31O31
2570.07
10.55
+3
2.07
0.252
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
32-64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

inst Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-64 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP

Other

P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-64 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast
Evidence 7 Activity

Activity

MIC
Antifungal
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM),
Evidence 8 Activity

Activity

MIC
Antifungal
32-64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-
Evidence 9 Activity

Activity

MIC
Antifungal
0.5 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-64 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
32 µM

Target

S. cerevisiae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-64 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast
Evidence 12 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM),
Evidence 13 Activity

Activity

MIC
Antiparasitic
32-64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

M. luteus

Source & Reference

dbAMP 3.0 DRAMP

Other

inst Gram- E. coli (MIC 4 uM), P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-64 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
32 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0 DRAMP

Other

P. aeruginosa (MIC 32 uM), Gram+ S. aureus (MIC 32-64 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 32 uM), and parasite T. brucei (LC95 2-64 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
50% Hemolysis | 128 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
16 µM
Cytotoxic
IC50 | 16 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.