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Peptide record

TPDB10657

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10657
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFGWLIRGAIHAGKAIHGLIHRRRH
Physicochemical Analysis
C136H211N47O26
NDCEQMPSTYV
RGHI
2920.47
12.88
9
0
12
+5
1.13
-0.024
105.60
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
188.33
0
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
0
E
0
Q
4
G
4
H
4
I
2
L
1
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 4 I: 4 L: 2 K: 1 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C136H211N47O26
2920.47
12.88
+5
1.13
-0.024
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

S. iniae F-8502

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harve
Evidence 2 Activity

Activity

MIC
Antibacterial
1.25 µM

Target

V. anguillarum ATCC 19264

Source & Reference

dbAMP DRAMP

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulnif
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µM

Target

A. salmonicida NCMB 1102

Source & Reference

dbAMP DRAMP

Other

MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 2.5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 5 uM), P-putida ATCC 12633 (MIC >40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 4 Activity

Activity

MIC
Antifungal
1.5 µM

Target

S. iniae F-8502

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harve
Evidence 5 Activity

Activity

MIC
Antifungal
1.25 µM

Target

V. anguillarum ATCC 19264

Source & Reference

dbAMP DRAMP Antifungipept

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulnif
Evidence 6 Activity

Activity

MIC
Antifungal
5 µM

Target

A. salmonicida NCMB 1102

Source & Reference

dbAMP DRAMP Antifungipept

Other

MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 2.5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 5 uM), P-putida ATCC 12633 (MIC >40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 7 Activity

Activity

MIC
Antiparasitic
1.5 µM

Target

S. iniae F-8502

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harve
Evidence 8 Activity

Activity

MIC
Antiparasitic
1.25 µM

Target

V. anguillarum ATCC 19264

Source & Reference

DRAMP

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulnif
Evidence 9 Activity

Activity

MIC
Antiparasitic
5 µM

Target

A. salmonicida NCMB 1102

Source & Reference

DRAMP

Other

MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 2.5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 5 uM), P-putida ATCC 12633 (MIC >40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 10 Activity

Activity

MIC
Antiviral
1.5 µM

Target

S. iniae F-8502

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harve
Evidence 11 Activity

Activity

MIC
Antiviral
1.25 µM

Target

V. anguillarum ATCC 19264

Source & Reference

DRAMP

Other

ainst Gram+ L. garvieae YT-3 (ATCC 49156) (MIC 5 uM), S. iniae F-8502 (MIC 1.5 uM), Gram- V. anguillarum ATCC 19264 (MIC 1.25 uM), Vibriopenaeicida KHA (MIC 5 uM), V. harveyi HUFP911 1 (ATCC 14126) (MIC 5 uM), V. vulnif
Evidence 12 Activity

Activity

MIC
Antiviral
5 µM

Target

A. salmonicida NCMB 1102

Source & Reference

DRAMP

Other

MIC 5 uM), V. vulnificus ET-7617(ATCC 33148) (MIC 2.5 uM), A-hydrophila ET-4 (MIC>40 uM), A. salmonicida NCMB 1102 (MIC 5 uM), P-putida ATCC 12633 (MIC >40 uM), and E-tarda ET-82016 (MIC>40 uM). Bactericidal activit
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
10 70 %
[Ref.12581207]10% hemolytic activity at 0.25 µM, 70% hemolytic activity at 1 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Eur J Biochem. 2003 Feb 270(4):675-686.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
1 µM
Hemolytic Cytotoxic
50% Hemolysis | 1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. | Eur J Biochem | 2003
Evidence 15 Activity

Activity

100% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
100% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. | Eur J Biochem | 2003
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.12581207]10% hemolytic activity at 0.25 µM, 70% hemolytic activity at 1 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2003 Feb 270(4):675-686.
Evidence 17 Hemolysis

Activity

10 70 %
% Hemolysis
[Ref.12581207]10% hemolytic activity at 0.25 µM, 70% hemolytic activity at 1 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Eur J Biochem. 2003 Feb 270(4):675-686.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.