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Peptide record

TPDB10652

Ple Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10652
Ple
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CancerPPD 2.0 SATPdb dbACP Antifungipept CAFPdb i2APP APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWGSFFKKAAHVGKHVGKAALTHYL
Physicochemical Analysis
C129H192N36O29
RNDCEQIMP
AGK
2711.17
10.64
7
0
12
+4
0.44
-0.068
70.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
257.82
3
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
3
H
0
I
2
L
4
K
0
M
2
F
0
P
1
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 3 I: 0 L: 2 K: 4 M: 0 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
25
C129H192N36O29
2711.17
10.64
+4
0.44
-0.068
Free
L
Linear
Free
Antimicrobial
Pleuronectes americanus
Evidence Records 85 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I o
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP DRAMP

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aerugin
Evidence 3 Activity

Activity

MIC
Antibacterial
2-17.7 µM

Target

S. enterica serovar Typhimurium MS7953s or 14028s or I or II

Source & Reference

dbAMP DRAMP

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

dbAMP DRAMP

Other

(MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicil
Evidence 5 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP DRAMP

Other

ium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM),
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP DRAMP

Other

, P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Al
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus C623 or MRSA

Source & Reference

dbAMP DRAMP

Other

4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonici
Evidence 8 Activity

Activity

MIC
Antibacterial
8 µM

Target

Candida albicans C627

Source & Reference

dbAMP DRAMP

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aerugino
Evidence 9 Activity

Activity

MIC
Antibacterial
2.2-3.3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

tant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM),
Evidence 10 Activity

Activity

MIC
Antibacterial
2-35 µM

Target

A. salmonicida

Source & Reference

dbAMP DRAMP

Other

A (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 u
Evidence 11 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

(MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtili
Evidence 12 Activity

Activity

MIC
Antibacterial
2.2-4.4 µM

Target

C. aquatilis

Source & Reference

dbAMP DRAMP

Other

ainst E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (
Evidence 13 Activity

Activity

MIC
Antibacterial
4.4-8.8 µM

Target

P. haemolytica

Source & Reference

dbAMP DRAMP

Other

A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (
Evidence 14 Activity

Activity

MIC
Antibacterial
1.1-2.2 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

IC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it
Evidence 15 Activity

Activity

MIC
Antibacterial
17.7-35 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacte
Evidence 16 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

(MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacteria S. mutans (UA 159, UA 1
Evidence 17 Activity

Activity

MIC
Antibacterial
2-32 µg/mL

Target

L. fermenti

Source & Reference

dbAMP DRAMP

Other

. sanguinis ATCC 10556 S. sobrinus ATCC 6715, S. gordonii ATCC 10558, L. casei ATCC 393, L. fermenti (MIC 2-32 ug/ml) ( Tao R et al., 2011 ). Antibiofilm:bacteria: this peptide disrupted bacterial biofilm:S.
Evidence 18 Activity

Activity

IC50
IC50 = 54.9 µM
Anticancer
54.9 µM

Target

Liver Cancer
J5
Liver

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2022

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 19 Activity

Activity

IC50
IC50 = 340.9 µM
Anticancer
340.9 µM

Target

Liver Cancer
Hep3B
Liver

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2022
Evidence 20 Activity

Activity

IC50
IC50 = 300.8 µM
Anticancer
300.8 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2022
Evidence 21 Activity

Activity

IC50
IC50 = 186.5 µM
Anticancer
186.5 µM

Target

Stomach Cancer
AGS
Stomach

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2022
Evidence 22 Activity

Activity

MIC
Antifungal
2 µM

Target

A. salmonicida 99-1

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I o
Evidence 23 Activity

Activity

MIC
Antifungal
2 µM

Target

A. salmonicida 97-4

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aerugin
Evidence 24 Activity

Activity

MIC
Antifungal
2-17.7 µM

Target

S. enterica serovar Typhimurium MS7953s or 14028s or I or II

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM),
Evidence 25 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicil
Evidence 26 Activity

Activity

MIC
Antifungal
2-4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM),
Evidence 27 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Al
Evidence 28 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus C623 or MRSA

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonici
Evidence 29 Activity

Activity

MIC
Antifungal
8 µM

Target

Candida albicans C627

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aerugino
Evidence 30 Activity

Activity

MIC
Antifungal
2.2-3.3 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

tant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM),
Evidence 31 Activity

Activity

MIC
Antifungal
2-35 µM

Target

A. salmonicida

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

A (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 u
Evidence 32 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtili
Evidence 33 Activity

Activity

MIC
Antifungal
2.2-4.4 µM

Target

C. aquatilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ainst E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (
Evidence 34 Activity

Activity

MIC
Antifungal
4.4-8.8 µM

Target

P. haemolytica

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (
Evidence 35 Activity

Activity

MIC
Antifungal
1.1-2.2 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it
Evidence 36 Activity

Activity

MIC
Antifungal
17.7-35 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacte
Evidence 37 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacteria S. mutans (UA 159, UA 1
Evidence 38 Activity

Activity

MIC
Antifungal
2-32 µg/mL

Target

L. fermenti

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. sanguinis ATCC 10556 S. sobrinus ATCC 6715, S. gordonii ATCC 10558, L. casei ATCC 393, L. fermenti (MIC 2-32 ug/ml) ( Tao R et al., 2011 ). Antibiofilm:bacteria: this peptide disrupted bacterial biofilm:S.
Evidence 39 Activity

Activity

MIC
Antiparasitic
2 µM

Target

A. salmonicida 99-1

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I o
Evidence 40 Activity

Activity

MIC
Antiparasitic
2 µM

Target

A. salmonicida 97-4

Source & Reference

DRAMP

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aerugin
Evidence 41 Activity

Activity

MIC
Antiparasitic
2-17.7 µM

Target

S. enterica serovar Typhimurium MS7953s or 14028s or I or II

Source & Reference

DRAMP

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM),
Evidence 42 Activity

Activity

MIC
Antiparasitic
4-8 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

DRAMP

Other

(MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicil
Evidence 43 Activity

Activity

MIC
Antiparasitic
2-4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

DRAMP

Other

ium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM),
Evidence 44 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

DRAMP

Other

, P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Al
Evidence 45 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus aureus C623 or MRSA

Source & Reference

DRAMP

Other

4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonici
Evidence 46 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Candida albicans C627

Source & Reference

DRAMP

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aerugino
Evidence 47 Activity

Activity

MIC
Antiparasitic
2.2-3.3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

tant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM),
Evidence 48 Activity

Activity

MIC
Antiparasitic
2-35 µM

Target

A. salmonicida

Source & Reference

DRAMP

Other

A (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 u
Evidence 49 Activity

Activity

MIC
Antiparasitic
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

(MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtili
Evidence 50 Activity

Activity

MIC
Antiparasitic
2.2-4.4 µM

Target

C. aquatilis

Source & Reference

DRAMP

Other

ainst E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (
Evidence 51 Activity

Activity

MIC
Antiparasitic
4.4-8.8 µM

Target

P. haemolytica

Source & Reference

DRAMP

Other

A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (
Evidence 52 Activity

Activity

MIC
Antiparasitic
1.1-2.2 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

IC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it
Evidence 53 Activity

Activity

MIC
Antiparasitic
17.7-35 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacte
Evidence 54 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

(MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacteria S. mutans (UA 159, UA 1
Evidence 55 Activity

Activity

MIC
Antiparasitic
2-32 µg/mL

Target

L. fermenti

Source & Reference

DRAMP

Other

. sanguinis ATCC 10556 S. sobrinus ATCC 6715, S. gordonii ATCC 10558, L. casei ATCC 393, L. fermenti (MIC 2-32 ug/ml) ( Tao R et al., 2011 ). Antibiofilm:bacteria: this peptide disrupted bacterial biofilm:S.
Evidence 56 Activity

Activity

MIC
Antiviral
2 µM

Target

A. salmonicida 99-1

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I o
Evidence 57 Activity

Activity

MIC
Antiviral
2 µM

Target

A. salmonicida 97-4

Source & Reference

DRAMP

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aerugin
Evidence 58 Activity

Activity

MIC
Antiviral
2-17.7 µM

Target

S. enterica serovar Typhimurium MS7953s or 14028s or I or II

Source & Reference

DRAMP

Other

Highly active against A. salmonicida 99-1 (MIC 2 uM), A. salmonicida 97-4 (MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM),
Evidence 59 Activity

Activity

MIC
Antiviral
4-8 µM

Target

Pseudomonas aeruginosa K799 or Z61

Source & Reference

DRAMP

Other

(MIC 2 uM), S. enterica serovar Typhimurium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicil
Evidence 60 Activity

Activity

MIC
Antiviral
2-4 µM

Target

Escherichia coli CGSC4908 or UB1005 or DC2

Source & Reference

DRAMP

Other

ium MS7953s or 14028s or I or II (MIC 2-17.7 uM), P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM),
Evidence 61 Activity

Activity

MIC
Antiviral
8 µM

Target

Staphylococcus epidermidis C621

Source & Reference

DRAMP

Other

, P. aeruginosa K799 or Z61 (MIC 4-8 uM), E. coli CGSC4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Al
Evidence 62 Activity

Activity

MIC
Antiviral
8 µM

Target

Staphylococcus aureus C623 or MRSA

Source & Reference

DRAMP

Other

4908 or UB1005 or DC2 (MIC 2-4 uM), S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonici
Evidence 63 Activity

Activity

MIC
Antiviral
8 µM

Target

Candida albicans C627

Source & Reference

DRAMP

Other

S. epidermidis C621 (MIC 8 uM), methicillin-resistant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aerugino
Evidence 64 Activity

Activity

MIC
Antiviral
2.2-3.3 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

tant S. aureus C623 or MRSA (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM),
Evidence 65 Activity

Activity

MIC
Antiviral
2-35 µM

Target

A. salmonicida

Source & Reference

DRAMP

Other

A (MIC 8 uM), C. albicans C627 (MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 u
Evidence 66 Activity

Activity

MIC
Antiviral
4-8 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

(MIC 8 uM). Also, active against E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtili
Evidence 67 Activity

Activity

MIC
Antiviral
2.2-4.4 µM

Target

C. aquatilis

Source & Reference

DRAMP

Other

ainst E. coli (MIC 2.2-3.3 uM), A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (
Evidence 68 Activity

Activity

MIC
Antiviral
4.4-8.8 µM

Target

P. haemolytica

Source & Reference

DRAMP

Other

A. salmonicida (MIC 2-35 uM), P. aeruginosa (MIC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (
Evidence 69 Activity

Activity

MIC
Antiviral
1.1-2.2 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

IC 4-8 uM) C. aquatilis (MIC 2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it
Evidence 70 Activity

Activity

MIC
Antiviral
17.7-35 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

2.2-4.4 uM), P. haemolytica (MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacte
Evidence 71 Activity

Activity

MIC
Antiviral
8 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

(MIC 4.4-8.8 uM), Gram-positive B. subtilis (MIC 1.1-2.2 uM), S. aureus (MIC 17.7-35 uM), S. epidermidis (MIC 8 uM), and C. albicans. In addition, it is active against oral bacteria S. mutans (UA 159, UA 1
Evidence 72 Activity

Activity

MIC
Antiviral
2-32 µg/mL

Target

L. fermenti

Source & Reference

DRAMP

Other

. sanguinis ATCC 10556 S. sobrinus ATCC 6715, S. gordonii ATCC 10558, L. casei ATCC 393, L. fermenti (MIC 2-32 ug/ml) ( Tao R et al., 2011 ). Antibiofilm:bacteria: this peptide disrupted bacterial biofilm:S.
Evidence 73 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of cationic antimicrobial peptides with improved activity and selectivity against Vibrio spp. | Int J Antimicrob Agents | 2008
Evidence 74 Activity

Activity

6% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
6% Hemolysis | 100 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Interaction of pleurocidin and its analogs with phospholipid membrane and their antibacterial activity. | J Pept Res | 2001
Evidence 75 Activity

Activity

50% Cell death
Toxicity
350 µM
Cytotoxic
50% Cell death | 350 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy. | Mol Cell Biochem | 2015
Evidence 76 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-antimicrobial activity relationship between pleurocidin and its enantiomer. | Exp Mol Med | 2008
Evidence 77 Activity

Activity

29% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
29% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-antimicrobial activity relationship between pleurocidin and its enantiomer. | Exp Mol Med | 2008
Evidence 78 Activity

Activity

77% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
77% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-antimicrobial activity relationship between pleurocidin and its enantiomer. | Exp Mol Med | 2008
Evidence 79 Activity

Activity

50% Cell death
Toxicity
56 µM
Cytotoxic
50% Cell death | 56 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antimicrobial peptide GW-H1-induced apoptosis of human gastric cancer AGS cell line is enhanced by suppression of autophagy. | Mol Cell Biochem | 2015
Evidence 80 Activity

Activity

7% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
7% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Influence of the hydrophobic amino acids in the N- and C-terminal regions of pleurocidin on antifungal activity. | J Microbiol Biotechnol | 2010
Evidence 81 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 82 Activity

Activity

100% Killing
Toxicity
5 µM
Cytotoxic
100% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 83 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 84 Activity

Activity

3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes. | Int J Antimicrob Agents | 2011
Evidence 85 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.