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Peptide record

TPDB10648

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10648
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GWASSIGSILGKFAKGGAQAFLQPK
Physicochemical Analysis
C117H183N31O31
RNDCEHMTYV
G
2519.93
10.84
3
0
11
+3
-1.51
0.152
78.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
218.26
5
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
2
Q
5
G
0
H
2
I
2
L
3
K
0
M
2
F
1
P
3
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 5 H: 0 I: 2 L: 2 K: 3 M: 0 F: 2 P: 1 S: 3 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C117H183N31O31
2519.93
10.84
+3
-1.51
0.152
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 2 Activity

Activity

MIC
Antibacterial
>256 µM

Target

S.aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4
Evidence 3 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

M. luteus

Source & Reference

dbAMP

Other

gainst Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

M), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
32 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 6 Activity

Activity

MIC
Antifungal
>256 µM

Target

S.aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4
Evidence 7 Activity

Activity

MIC
Antifungal
0.5 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

gainst Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
32 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 10 Activity

Activity

MIC
Antiparasitic
>256 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4
Evidence 11 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

gainst Gram- E. coli (MIC 32 uM), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

M), Paeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC95 4 uM).
Evidence 13 Activity

Activity

50% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
50% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 14 Activity

Activity

IC50
Toxicity
64 µM
Cytotoxic
IC50 | 64 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 15 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.