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Peptide record

TPDB10646

Antibacterial Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10646
Antibacterial Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GFMSKVANFAKKFAKGGVNAIMNQK
Physicochemical Analysis
C121H196N34O31S2
RDCEHLPTWY
K
2687.22
11.12
5
0
12
+5
2.25
-0.128
54.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
4
A
0
R
3
N
0
D
0
C
0
E
1
Q
3
G
0
H
1
I
0
L
5
K
2
M
3
F
0
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 3 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 0 K: 5 M: 2 F: 3 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
25
C121H196N34O31S2
2687.22
11.12
+5
2.25
-0.128
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

M. luteus

Source & Reference

dbAMP

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
1 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 7 Activity

Activity

MIC
Antifungal
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and
Evidence 8 Activity

Activity

MIC
Antifungal
128 µM

Target

S.aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8
Evidence 9 Activity

Activity

MIC
Antifungal
0.5 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
1 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 12 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and
Evidence 13 Activity

Activity

MIC
Antiparasitic
128 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.5 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
1 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S.
Evidence 17 Activity

Activity

MIC
Antiviral
4 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and
Evidence 18 Activity

Activity

MIC
Antiviral
128 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8
Evidence 19 Activity

Activity

MIC
Antiviral
0.5 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

against Gram- E. coli (MIC 1 uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 20 Activity

Activity

MIC
Antiviral
8 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

uM), P. aeruginosa (MIC 4 uM), Gram+ S.aureus (MIC 128 uM), M. luteus (MIC 0.5 uM), yeast S. cerevisiae (MIC 8 uM), and parasite T. brucei (LC95 1-8 uM).
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
50% Hemolysis | 64 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 22 Activity

Activity

IC50
Toxicity
16 µM
Cytotoxic
IC50 | 16 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 23 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.