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Peptide record

TPDB10639

Antibacterial Antifungal Antiviral Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10639
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLFGILGSVAKHVLPHVIPVVAEHL
Physicochemical Analysis
C124H200N32O29
RNDCQMTWY
V
2603.15
8.06
4
1
14
+0
2.97
1.176
159.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
3
G
3
H
2
I
4
L
1
K
0
M
1
F
2
P
1
S
0
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 3 I: 2 L: 4 K: 1 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 5
Chemical Descriptors
25
C124H200N32O29
2603.15
8.06
+0
2.97
1.176
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

L. lactis

Source & Reference

dbAMP

Other

Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

L. innocua

Source & Reference

dbAMP

Other

ive against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

(MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multoc
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

S. uberis

Source & Reference

dbAMP

Other

20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also,
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP

Other

5923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibi
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

E.coli

Source & Reference

dbAMP

Other

ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibit HIV infection ( VanCom
Evidence 9 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.multocida

Source & Reference

dbAMP

Other

5 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibit HIV infection ( VanCompernolle et al., 2015 ). Updated
Evidence 10 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus
Evidence 11 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP Antifungipept

Other

Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATC
Evidence 12 Activity

Activity

MIC
Antifungal
25 µM

Target

L. lactis

Source & Reference

dbAMP Antifungipept

Other

Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC
Evidence 13 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

L. innocua

Source & Reference

dbAMP Antifungipept

Other

ive against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis
Evidence 14 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP Antifungipept

Other

(MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multoc
Evidence 15 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

S. uberis

Source & Reference

dbAMP Antifungipept

Other

20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also,
Evidence 16 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP Antifungipept

Other

5923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibi
Evidence 17 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

E.coli

Source & Reference

dbAMP Antifungipept

Other

ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibit HIV infection ( VanCom
Evidence 18 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.multocida

Source & Reference

dbAMP Antifungipept

Other

5 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibit HIV infection ( VanCompernolle et al., 2015 ). Updated
Evidence 19 Activity

Activity

MIC
Antiviral
100 µg/mL

Target

B. cereus

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus
Evidence 20 Activity

Activity

MIC
Antiviral
>100 µg/mL

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATC
Evidence 21 Activity

Activity

MIC
Antiviral
25 µM

Target

L. lactis

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Active against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC
Evidence 22 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

L. innocua

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

ive against B. cereus (MIC 100 ug/ml), E.faecalis (MIC>100 ug/ml), L. lactis (MIC 25 uM), L. innocua (MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis
Evidence 23 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

(MIC 25 ug/ml), M. luteus (MIC 20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multoc
Evidence 24 Activity

Activity

MIC
Antiviral
50 µg/mL

Target

S. uberis

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

20 ug/ml, S. aureus ATCC 25923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also,
Evidence 25 Activity

Activity

MIC
Antiviral
>100 µg/mL

Target

E.clocae

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

5923, or 29213 (MIC 25-50 ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibi
Evidence 26 Activity

Activity

MIC
Antiviral
>100 µg/mL

Target

E.coli

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

ug/ml, S. epidermidis (MIC 25 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibit HIV infection ( VanCom
Evidence 27 Activity

Activity

MIC
Antiviral
>100 µg/mL

Target

P.multocida

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

5 ug/ml), S. uberis (MIC 50 ug/ml), E.clocae (MIC>100 ug/ml), E.coli (MIC>100 ug/ml), and P.multocida (MIC>100 ug/ml). Also, this peptide could inhibit HIV infection ( VanCompernolle et al., 2015 ). Updated
Evidence 28 Activity

Activity

50% Cell death
Toxicity
25 µM
Cytotoxic
50% Cell death | 25 | µM | target cell: CD4+ T Lymphocytes

Target

CD4+ T Lymphocytes

Source & Reference

NA
DBAASP
Inhibition of HIV Infection by Caerin 1 Antimicrobial Peptides | Peptides | 2015
Evidence 29 Activity

Activity

50% Cell death
Toxicity
22 µM
Cytotoxic
50% Cell death | 22 | µM | target cell: Human endocervical cells End1/E6E7

Target

Human endocervical cells End1/E6E7

Source & Reference

NA
DBAASP
Inhibition of HIV Infection by Caerin 1 Antimicrobial Peptides | Peptides | 2015
Evidence 30 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 25 µM Human endocervical cells End1/E6E7:50% cell death at 22 µM.

Source & Reference

NA
DRAMP
Peptides. 2015 Sep 71:296-303.##Antibiotics (Basel). 2020 Sep 30 9(10):661.