TPDB

3D PDB MODEL

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TPDB ID TPDB10638

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 25-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

APAHRSSTFPKWVTKTERGRQPLRS

FASTA

>TPDB10638|Antibacterial;Antifungal;Toxicity|length=25
APAHRSSTFPKWVTKTERGRQPLRS

Formula C127H205N43O35

Absent Amino Acids NDCIMY

Common Amino Acids R

Mass 2894.29

PI 12.41

Basic Residues 7

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +5

Boman Index 7.14

Hydrophobicity -1.288

Aliphatic Index 35.20

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 190.03

Polar Residues 7

number

2

A

4

R

0

N

0

D

0

C

1

E

1

Q

1

G

1

H

0

I

1

L

2

K

0

M

1

F

3

P

3

S

3

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 4 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 1 H: 1 I: 0 L: 1 K: 2 M: 0 F: 1 P: 3 S: 3 T: 3 W: 1 Y: 0 V: 1

Length

25

Formula

C127H205N43O35

Mass

2894.29

PI

12.41

Net Charge

+5

Boman Index

7.14

Hydrophobicity

-1.288

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

In 2013, this peptide was demonstrated to have antimicrobial activity as well. Diffusion assay: Active against Gram-negative E. coli ML-35 (3 mm at 100 pmol).

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

In 2013, this peptide was demonstrated to have antimicrobial activity as well. Diffusion assay: Active against Gram-negative E. coli ML-35 (3 mm at 100 pmol).

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

NA | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity. | Biochem Biophys Res Commun | 2013