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Peptide record

TPDB10637

Antibacterial Antifungal Hemolysis Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB10637
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GVWTTILGGLKKFAKGGLEALTNPK
Physicochemical Analysis
C121H199N31O32
RDCQHMSY
G
2600.10
10.55
4
1
10
+3
1.52
0.044
97.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
211.53
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
5
G
0
H
1
I
4
L
4
K
0
M
1
F
1
P
0
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 5 H: 0 I: 1 L: 4 K: 4 M: 0 F: 1 P: 1 S: 0 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
25
C121H199N31O32
2600.10
10.55
+3
1.52
0.044
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
40 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
weakly active against E. coli (MIC 40 uM) and S. aureus (MIC 80 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
80 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

weakly active against E. coli (MIC 40 uM) and S. aureus (MIC 80 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
40 µM

Target

Escherichia coli

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
weakly active against E. coli (MIC 40 uM) and S. aureus (MIC 80 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
80 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP Antifungipept

Other

weakly active against E. coli (MIC 40 uM) and S. aureus (MIC 80 uM).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
50% Hemolysis | 60 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). | Peptides | 2012
Evidence 6 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.